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Updated: Sep 7, 2025
Experimental Demyelination and Remyelination of Murine Spinal Cord by Focal Injection of Lysolecithin
Published on: March 26, 2015
Progressive myelin oligodendrocyte glycoprotein-associated demyelination mimicking leukodystrophy
Emily Gibbons1, Daniel Whittam2, Kariem Elhadd1
1National Neuromyelitis Optica Spectrum Disorders Service, The Walton Centre NHS Foundation Trust, Liverpool, UK.
Background:
Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) may be associated with relapsing disease, but clinical progression independent of relapse activity is rare.
Objectives:
To report progressive disease in a patient with MOGAD.
Methods:
A single retrospective case report.
Results:
At 4 years of age, the patient had a single episode of acute disseminated encephalomyelitis. She remained well until age 17 years but over the next 9 years developed progressive spastic quadriparesis, cognitive and bulbar dysfunction. Brain imaging showed a leukodystrophy-like pattern of white matter abnormality with contrast enhancement at different time points. Myelin oligodendrocyte glycoprotein (MOG)-IgG was repeatedly positive by live cell-based assay.
Conclusion:
Secondary progression may be a rare presentation of MOG-IgG-associated disease.
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