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Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
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Combined cardiomegaly and aortic arch calcification predict mortality in hemodialysis patients

Yit-Sheung Yap1, Wen-Che Chi1, Cheng-Hao Lin1

  • 1Division of Nephrology, Department of Internal Medicine, Yuan's General Hospital, Kaohsiung, Taiwan.

Therapeutic Apheresis and Dialysis : Official Peer-Reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy
|June 23, 2022
PubMed

Insights

Cardiomegaly and aortic arch calcification (AAC) significantly predict mortality in hemodialysis patients. Combined findings indicate increased risk for overall and cardiovascular death.

Area of Science:

  • Nephrology
  • Cardiology
  • Radiology

Background:

  • Cardiomegaly and aortic arch calcification (AAC) are common in hemodialysis patients.
  • The prognostic value of combined cardiomegaly and AAC on mortality requires further investigation.

Purpose of the Study:

  • To investigate the association between cardiomegaly and AAC with overall and cardiovascular mortality in hemodialysis patients.

Main Methods:

  • Retrospective cohort study of hemodialysis patients.
  • Cardiomegaly (cardiothoracic ratio, CTR) and AAC assessed by chest radiography.
  • Patients categorized by CTR (≤0.5 vs. >0.5) and AAC grade (low/high).
  • Mortality risk analyzed using Cox proportional hazards models.

Main Results:

  • Multivariate analysis revealed significant associations between combined CTR and AAC grades with overall mortality.
  • Specific combinations, such as CTR >0.5 with low-grade AAC and CTR >0.5 with high-grade AAC, showed elevated risks.
  • Similarly, combined CTR and AAC grades were significantly related to cardiovascular mortality.

Conclusions:

  • The combination of cardiomegaly and aortic arch calcification serves as a significant predictor of both overall and cardiovascular mortality in patients undergoing hemodialysis.
Abstract

Keywords:
artic arch calcificationcardiomegalycardiovascular mortalityhemodialysisoverall mortality

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