Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Immunodeficiency Diseases01:25

Immunodeficiency Diseases

1.2K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
1.2K
Immunological Memory01:23

Immunological Memory

4.6K
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
4.6K
T Cell Types and Functions01:24

T Cell Types and Functions

1.4K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.4K
Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

61
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
61
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

71.6K
Overview
71.6K
Autoimmune Disorders01:29

Autoimmune Disorders

661
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
661

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Metabolic dysfunction-associated steatotic liver disease and metabolic dysfunction-associated alcohol-related liver disease represent distinct clinical phenotypes and fibrosis risk: insights from a population-based Polish cohort.

Polish archives of internal medicine·2026
Same author

Prevalence of hearing loss and other ear disorders among patients with hepatitis B infection: a nationwide retrospective Polish cohort study.

Scientific reports·2026
Same author

Recommendations for hypolipidemic and antithrombotic therapy in HCV-infected patients treated with direct-acting antiviral agents: expert position statement.

Clinical and experimental hepatology·2026
Same author

Disease-modifying treatment for multiple sclerosis in Poland in a European context: current practices and therapeutic strategies.

Neurologia i neurochirurgia polska·2026
Same author

First documented case of Zika virus infection in a Polish patient - diagnostic traps. Case report.

Annals of agricultural and environmental medicine : AAEM·2026
Same author

Clinical characteristics of hospitalized patients with hepatitis E virus infection in Poland: a multi-centre retrospective study.

Advances in medical sciences·2026

Related Experiment Video

Updated: Sep 7, 2025

Author Spotlight: Novel Assay for Studying B-Cell Responses in Multiple Sclerosis Research
05:55

Author Spotlight: Novel Assay for Studying B-Cell Responses in Multiple Sclerosis Research

Published on: December 1, 2023

962

Immunosenescence and multiple sclerosis.

Monika Adamczyk-Sowa1, Maria Nowak-Kiczmer2, Jerzy Jaroszewicz3

  • 1Department of Neurology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Zabrze, Poland. m.adamczyk.sowa@gmail.com.

Neurologia I Neurochirurgia Polska
|June 23, 2022
PubMed
Summary

Ageing of the immune system, or immunosenescence, leads to reduced immune response and increased inflammation. This impacts chronic diseases like multiple sclerosis (MS) and the effectiveness of its treatments.

Keywords:
DMTsimmunosenescenceinflamm-ageingmultiple sclerosis

More Related Videos

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination
09:38

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination

Published on: September 12, 2016

12.4K
Induction and Diverse Assessment Indicators of Experimental Autoimmune Encephalomyelitis
06:19

Induction and Diverse Assessment Indicators of Experimental Autoimmune Encephalomyelitis

Published on: September 9, 2022

3.8K

Related Experiment Videos

Last Updated: Sep 7, 2025

Author Spotlight: Novel Assay for Studying B-Cell Responses in Multiple Sclerosis Research
05:55

Author Spotlight: Novel Assay for Studying B-Cell Responses in Multiple Sclerosis Research

Published on: December 1, 2023

962
Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination
09:38

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination

Published on: September 12, 2016

12.4K
Induction and Diverse Assessment Indicators of Experimental Autoimmune Encephalomyelitis
06:19

Induction and Diverse Assessment Indicators of Experimental Autoimmune Encephalomyelitis

Published on: September 9, 2022

3.8K

Area of Science:

  • Immunology
  • Gerontology
  • Neuroimmunology

Background:

  • Immunosenescence, the ageing of the immune system, is marked by declining immune function, chronic inflammation ('inflamm-ageing'), and heightened autoimmune disease risk.
  • Key changes include reduced naive T and B cells, NK cells, and altered cytokine production, disrupting immune balance.
  • Causes are multifactorial, involving senescence, chronic illness, lifestyle, environment, epigenetics, and infections.

Purpose of the Study:

  • To explore the influence of immunosenescence on the progression of multiple sclerosis (MS).
  • To investigate how immunosenescence affects the safety and efficacy of disease-modifying therapies (DMTs) in MS patients.
  • To highlight the need for further research into the interplay between MS pathogenesis and immune system ageing.

Main Methods:

  • This study is a review and analysis of existing literature on immunosenescence and its impact on MS.
  • It synthesizes findings on immune system changes associated with ageing in both healthy individuals and MS patients.
  • The review examines the implications of these changes for disease course and treatment outcomes.

Main Results:

  • Features of immunosenescence are observed in MS patients at younger ages compared to healthy controls.
  • Immunosenescence contributes to increased susceptibility to infections, poor vaccine response, and higher risks of cancer, vascular diseases, and neurodegeneration in the elderly.
  • These age-related immune changes significantly influence MS progression and the effectiveness of current treatments.

Conclusions:

  • Immunosenescence is a critical factor affecting the course of MS and the outcomes of DMTs.
  • Understanding the relationship between MS pathology and immune ageing is crucial for developing better therapeutic strategies.
  • Further investigation is warranted to elucidate the complex interactions between immunosenescence and the development and progression of MS.