[Clinical and epidemiological features of SARS-CoV-2 infection in children under 16 years of age]
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Updated: Sep 7, 2025

Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses
Published on: November 10, 2023
Julia Alonso de la Hoz1, Arantxa Vidal Esteban1, Susana de Las Heras Ibarra1
1Hospital Universitario de Fuenlabrada, Madrid, España.
Insights
In children under 16, SARS-CoV-2 infection presented with fever and respiratory symptoms, with nearly 5% requiring hospitalization. Identifying close contacts was challenging in many pediatric cases.
Area of Science:
- Pediatric Infectious Diseases
- Epidemiology
- Public Health
Background:
- Limited data exists on pediatric SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) infections compared to adults.
- Understanding transmission, symptoms, and effective treatments in children is crucial during the pandemic.
Purpose of the Study:
- To analyze the clinical and epidemiological characteristics of SARS-CoV-2 infection in children under 16 years of age.
- To identify key symptoms, risk factors, and outcomes in the pediatric population.
Main Methods:
- A descriptive study was conducted on children tested for SARS-CoV-2 RNA.
- Data included epidemiological factors, symptoms, and signs of infection from 1378 pediatric patients.
- Testing was performed due to symptoms, close contact, or hospitalization/surgical needs.
Main Results:
- 12% (165 out of 1378) of pediatric patients tested positive for SARS-CoV-2.
- Fever, runny nose, and cough were the most frequent symptoms; digestive issues were also noted.
- 4.8% of positive pediatric cases required hospitalization; one case of COVID-19 pneumonia and two cases of MIS-C were observed.
Conclusions:
- SARS-CoV-2 infection is generally milder in children, but hospitalization is still required for a small percentage.
- A significant proportion of cases (61%) lacked identified close contacts, complicating transmission tracking.
- Further research across all care levels is needed to fully characterize pediatric SARS-CoV-2 infection.
Introduction:
During the SARS-CoV-2 pandemic, efforts have focused on trying to identify the routes of transmis sion of the virus, characterize its symptoms and signs, and investigate the best diagnostic and thera peutic methods. There are fewer published data and series in the pediatric population than in adults.
Objective:
To analyze the clinical and epidemiological characteristics in children under 16 years of age diagnosed with SARS-CoV-2.
Patients And Method:
Descriptive study carried out on children who underwent SARS-CoV-2 RNA testing due to compatible symptoms, close contact, or requiring hospitalization or surgery, in the Emergency Department of a hospital in Madrid, Spain. 30 variables were collected including epidemiological data, symptoms, and signs of infection.
Results:
Out of 1378 patients, 12% were positive (165). There was a higher proportion of patients of North African origin in the positive group than in the negative one (p < 0.01). Of all patients, 35.6% reported close contact with a confirmed case, which was more frequent in the positive group. 75.8% of the positive patients had some symptoms, most frequently fever, runny nose, and cough, followed by digesti ve symptoms. There was one case of COVID-19 pneumonia and two patients with MIS-C, one of which had SARS-CoV-2 infection. Eight of the positive patients (4.8%) required hospitalization due to SARS-CoV-2 infection.
Conclusion:
Although SARS-CoV-2 infection is milder in the pediatric population, almost 5% will require hospitalization. No close contact was identified in a high percen tage of patients (61%). Further studies are needed at all levels of care to characterize the infection in children and adolescents.
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