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Outcomes of Geriatric Patients with Hepatocellular Carcinoma

Chern-Horng Lee1, Tzung-Hai Yen2,3, Sen-Yung Hsieh3,4

  • 1Division of General Internal Medicine and Geriatrics, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan 333, Taiwan.

Current Oncology (Toronto, Ont.)
|June 23, 2022
PubMed

Insights

Geriatric patients (65-75 years) with hepatocellular carcinoma (HCC) have similar outcomes to younger patients within the first three years. Aggressive management is recommended for elderly HCC patients, as age is not an independent mortality factor.

Area of Science:

  • Hepatology
  • Geriatric Medicine
  • Oncology

Background:

  • Hepatocellular carcinoma (HCC) treatment and outcomes in geriatric patients are debated.
  • This study compares geriatric and younger HCC patient outcomes.

Purpose of the Study:

  • To investigate if age impacts hepatocellular carcinoma (HCC) survival rates.
  • To determine if geriatric HCC patients require different management strategies.

Main Methods:

  • Retrospective cohort study of 11,033 HCC patients (2001-2017).
  • Propensity score matching (1:2) used to compare geriatric (65-75 years) and younger (<65 years) groups.
  • Kaplan-Meier and Fine-Gray competing risk models analyzed survival data.

Main Results:

  • No significant difference in 3-year HCC outcomes between geriatric and younger patients (p=0.060).
  • Age was not an independent predictor of mortality in HCC patients within 3 years.
  • Key survival factors included systemic immune-inflammation index (SII), tumor stage, and MELD score.

Conclusions:

  • Geriatric status does not independently affect HCC mortality within the initial 3 years.
  • Elderly patients with hepatocellular carcinoma should receive aggressive treatment comparable to younger individuals.

Keywords:
geriatric patientshepatocellular carcinomamortality

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