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Poloxamer-Based Scaffolds for Tissue Engineering Applications: A Review.

Naiyu Cui1, Chun-Yu Dai1, Xuran Mao1

  • 1The CONVERSATIONALIST Club, School of Stomatology, Shandong First Medical University and Shandong Academy of Medical Sciences, Tai'an 271016, China.

Gels (Basel, Switzerland)
|June 23, 2022
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Summary

Poloxamer hydrogels are versatile, injectable scaffolds for tissue engineering, supporting cell growth and forming vascular networks. Their potential in bone, cartilage, and nerve regeneration, as well as 3D printing bio-inks, is significant but requires further exploration.

Keywords:
3D printingbiomaterialshydrogel scaffoldspoloxamertissue engineering

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Tissue Engineering

Background:

  • Poloxamers are amphiphilic, thermally responsive triblock copolymers with broad biomedical applications.
  • Poloxamer hydrogels serve as injectable scaffolds for cells and growth factors (GFs) in tissue engineering.
  • These hydrogels offer benefits like injectability, low toxicity, and the ability to form vascular networks.

Purpose of the Study:

  • To review the latest advancements in poloxamer-based scaffolds for tissue engineering.
  • To discuss the application of poloxamers in various regenerative medicine fields.
  • To highlight the role of poloxamers in 3D printing bio-inks.

Main Methods:

  • Literature review of recent research on poloxamer hydrogels.
  • Analysis of poloxamer applications in bone, vascular, cartilage, skin, and nervous system tissue engineering.
  • Examination of poloxamers as bio-inks for 3D printing.

Main Results:

  • Poloxamer hydrogels demonstrate efficacy as injectable scaffolds, maintaining cell/GF integrity and promoting microenvironment formation.
  • Applications span diverse tissue types, including bone, cartilage, vascular, skin, and neural regeneration.
  • Poloxamers show promise as bio-inks for 3D bioprinting, enabling complex scaffold fabrication.

Conclusions:

  • Poloxamer hydrogels are highly promising biomaterials for tissue engineering and regenerative medicine.
  • Further research is needed to overcome biological challenges and fully realize the potential of poloxamer-based scaffolds.
  • Poloxamers are valuable components for advanced tissue engineering scaffolds and 3D printing applications.