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Updated: Sep 7, 2025

Genome-wide Analysis of Histone Modifications Distribution using the Chromatin Immunoprecipitation Sequencing Method in Magnaporthe oryzae
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Published on: June 2, 2021

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Regulatory Roles of Histone Modifications in Filamentous Fungal Pathogens

Yiling Lai1,2, Lili Wang1,3, Weilu Zheng1,3

  • 1CAS Key Laboratory of Insect Developmental and Evolutionary Biology, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences (CAS), Shanghai 200032, China.

Journal of Fungi (Basel, Switzerland)
|June 23, 2022
PubMed

Insights

Histone modifications regulate gene expression in fungal pathogens, impacting their development and ability to infect hosts. This review explores how histone methylation and acetylation control fungal pathogenicity and host interactions.

Area of Science:

  • Microbiology
  • Epigenetics
  • Plant Pathology
  • Mycology

Background:

  • Filamentous fungi employ diverse strategies to infect plants and insects.
  • Successful infection necessitates precise regulation of fungal gene expression in response to host environments.
  • Transcriptional reprogramming is vital for fungal development and pathogenicity.

Purpose of the Study:

  • To review recent findings on histone methylation and acetylation in fungal pathogens.
  • To elucidate the regulatory mechanisms of these epigenetic modifications in fungal development and pathogenicity.
  • To explore the role of histone modifications in modulating host-pathogen interactions.

Main Methods:

  • Literature review of recent research on histone modifications in fungal pathogens.
  • Analysis of studies focusing on histone methylation and acetylation.
  • Synthesis of information on epigenetic regulation in fungal development and pathogenicity.

Main Results:

  • Histone post-translational modifications are key epigenetic regulators of gene expression in fungi.
  • Histone methylation and acetylation significantly influence fungal development, morphogenesis, and stress responses.
  • These epigenetic mechanisms are crucial for pathogenicity and the modulation of fungi-host interactions.

Conclusions:

  • Histone methylation and acetylation are critical for regulating fungal pathogenicity.
  • Understanding these epigenetic mechanisms offers insights into controlling pathogenic fungi and their interactions with hosts.
  • Further research into histone modifications can lead to novel strategies against fungal diseases.
Keywords:
filamentous fungal pathogensfungal pathogenicityhistone acetylationhistone methylationpathogenic fungi–host interactions

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