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The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
Managing pediatric psoriasis: update on treatments and challenges-a review
A A Hebert1, J Browning2, P C Kwong3
1UTHealth McGovern Medical School, Houston, TX, USA.
Insights
Pediatric psoriasis is often underdiagnosed and undertreated due to limited approved medications. This review explores challenges and treatments for children with psoriasis, aiming to improve care.
Area of Science:
- Dermatology
- Pediatrics
- Immunology
Background:
- Psoriasis is a chronic, immune-mediated inflammatory skin condition affecting children.
- Limited FDA-approved medications pose challenges for treating pediatric psoriasis.
Purpose of the Study:
- To review diagnostic and treatment challenges in pediatric psoriasis.
- To discuss approved and off-label therapeutic options for children and infants.
Main Methods:
- Literature search of PubMed and relevant publications.
- Exploration of disease characteristics, epidemiology, treatment, and access to care.
Main Results:
- Clinical diagnosis of pediatric psoriasis can be difficult.
- Lack of adult-approved medication data limits pediatric treatment options.
- Biologic agents in trials offer new hope but raise safety concerns for children.
Conclusions:
- Pediatric psoriasis is frequently underrecognized and undertreated.
- Clinicians must carefully weigh risks and benefits for pediatric psoriasis treatment strategies.
Background:
Psoriasis is a chronic, immune-mediated inflammatory disease with prominent cutaneous features, although the limited number of medications approved for pediatric psoriasis makes treating this population difficult. This review provides an overview of the challenges associated with diagnosing and treating pediatric psoriasis as well as the approved and off-label treatments for children and infants with psoriasis.
Methods:
Articles relevant to pediatric psoriasis were identified using a series of PubMed searches. Topics relevant to pediatric psoriasis were explored, including disease characteristics, epidemiology, treatment efficacy and safety, and access to care. Publications previously known to the authors were also included.
Results:
Clinical features of psoriasis can be challenging to identify clinically, and patients face challenges gaining access to treatment. Most medications that have been approved for adult psoriasis lack data and labeling to support safe and effective use in pediatric patients, and therefore access is limited. A growing number of clinical trials using biologic agents for pediatric psoriasis aim to broaden available treatment options but may also raise unique concerns associated with the use of these medications in children.
Conclusion:
Pediatric psoriasis is underrecognized and often undertreated. Clinicians must balance relative risks and potential benefits when developing a treatment strategy for these patients.
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