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Related Experiment Video

Updated: Sep 7, 2025

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
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Subthreshold depression - concept, operationalisation and epidemiological data. A scoping review.

Hans-Peter Volz1, Johanna Stirnweiß1, Siegfried Kasper2

  • 1Hospital for Psychiatry, Psychotherapy und Psychosomatic Medicine Schloss Werneck, Werneck, Germany.

International Journal of Psychiatry in Clinical Practice
|June 23, 2022
PubMed
Summary

Subthreshold depression (SD) definitions are inconsistent, leading to varied research data. However, SD significantly impacts quality of life, similar to major depression, suggesting therapeutic interventions are beneficial.

Keywords:
Subthreshold depressionepidemiologyoperationalisationsubsyndromal depressionsystematic review

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Area of Science:

  • Psychiatry
  • Mental Health Research

Background:

  • Current diagnostic systems define depression categorically.
  • Subthreshold depression (SD) is an area of growing research interest.
  • Existing definitions of depression lack consistency.

Purpose of the Study:

  • To conduct a scoping review of literature on subthreshold depression (SD) published between October 2011 and September 2020.
  • To analyze the heterogeneity in operationalization criteria for SD.
  • To propose a more homogeneous definition for SD.

Main Methods:

  • A scoping review methodology was employed.
  • Both electronic and manual literature search methods were utilized.
  • 64 relevant papers were selected from an initial pool of 1,160.

Main Results:

  • Operationalization criteria for SD are highly heterogeneous.
  • Epidemiological data for SD is consequently very inconsistent.
  • Significant overlap exists between definitions of SD and minor depression.

Conclusions:

  • Inconsistent definitions hinder clear conclusions regarding subthreshold depression (SD).
  • SD appears to impact quality of life comparably to major depression (MD).
  • Therapeutic interventions may benefit both SD and prevent its progression to MD.