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Updated: Sep 6, 2025

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
[Smoking-related interstitial lung diseases]
Sebastian Röhrich1, Benedikt H Heidinger2, Florian Prayer2
1Universitätsklinik für Radiologie und Nuklearmedizin, Medizinische Universität Wien, Währinger Gürtel 18-20, 1090, Wien, Österreich. sebastian.roehrich@meduniwien.ac.at.
Diagnosing smoking-related interstitial lung diseases requires a structured approach, with computed tomography being key. Early smoking cessation and steroids are vital for inflammatory types, while antifibrotics may help fibrotic forms.
Area of Science:
- Pulmonology
- Radiology
- Pathology
Background:
- Smoking-related interstitial lung diseases (SR-ILDs) are a diverse group of lung conditions.
- Accurate diagnosis of SR-ILDs is crucial for effective treatment and patient prognosis.
- A systematic approach is needed to navigate the diagnostic complexities of these diseases.
Purpose of the Study:
- To outline the most common smoking-related interstitial lung diseases.
- To present a structured diagnostic workflow for identifying SR-ILDs.
- To emphasize the role of imaging and multidisciplinary collaboration.
Main Methods:
- Review of common smoking-related interstitial lung diseases.
- Description of a structured diagnostic workflow.
- Highlighting the utility of computed tomography (CT) in diagnosis.
Main Results:
- Computed tomography (CT) plays a pivotal role in the diagnostic pathway for SR-ILDs.
- A standardized CT protocol and structured assessment enhance diagnostic accuracy.
- CT may decrease the need for invasive lung biopsies.
Conclusions:
- Smoking cessation and corticosteroid therapy are primary treatments for inflammatory SR-ILDs like respiratory bronchiolitis interstitial lung disease (RB-ILD) and desquamative interstitial pneumonia (DIP).
- Antifibrotic medications (nintedanib, pirfenidone) are options for fibrotic changes, such as in idiopathic pulmonary fibrosis (IPF).
- Interdisciplinary discussion is recommended for managing patients with suspected SR-ILDs.
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