Adjacent cartilage tissue structure after successful transplantation: a quantitative MRI study using T2 mapping and
Veronika Janacova1, Pavol Szomolanyi1,2, Alexandra Kirner3
1High-Field MR Centre, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, BT32, Lazarettgasse 14, 1090, Vienna, Austria.
European Radiology
|June 23, 2022
Summary
Gray-level co-occurrence matrix (GLCM) texture analysis enhances T2 mapping for evaluating knee cartilage after matrix-associated chondrocyte transplantation (MACT). This method reveals that repair and adjacent tissues integrate with the implant over time.
Area of Science:
- Orthopedics and Sports Medicine
- Radiology and Medical Imaging
- Biomaterials Science
Background:
- Matrix-associated chondrocyte transplantation (MACT) is a common procedure for knee cartilage repair.
- Assessing the quality and integration of repair tissue is crucial for long-term outcomes.
- Quantitative MRI techniques, including T2 mapping, show promise in evaluating cartilage repair.
Purpose of the Study:
- To evaluate the texture of repair tissue and adjacent tissue after MACT using gray-level co-occurrence matrix (GLCM) analysis on T2 quantitative maps.
- To assess changes in cartilage texture and T2 values at 12 and 24 months post-MACT.
- To determine if GLCM analysis improves the sensitivity of T2 mapping in detecting structural changes in knee cartilage.
Main Methods:
- Twenty patients undergoing MACT were scanned using a 3T MR scanner with a T2 mapping sequence at 12 and 24 months.
- T2 values and 20 GLCM features were analyzed for repair tissue, adjacent tissue, and reference cartilage.
- Linear mixed-effect models were used to compare T2 values and GLCM features between tissue types and time points.
Main Results:
- A significant decrease in T2 values was observed in repair cartilage over time (p < 0.001).
- Significant differences in GLCM features (autocorrelation, correlation, homogeneity, contrast, difference entropy) were found between repair and reference cartilage (p < 0.05).
- Repair and adjacent tissues showed increasing similarity to reference tissue over time, with significant temporal effects on most GLCM features (p ≤ 0.001).
Conclusions:
- GLCM analysis is a valuable addition to T2 mapping for evaluating knee cartilage after MACT, enhancing sensitivity to structural changes.
- The findings suggest that cartilage adjacent to the repair site undergoes healing and integration with the cartilage implant.
- This combined approach aids in monitoring the long-term success and biological integration of MACT procedures.
More Related Videos
Related Concept Videos
01:27Growth of Cartilage and Bone Tissue
3.5K
Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...
3.5K
01:24Tissue Transplantation
513
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
513