Effects of Backfat Thickness on Oxidative Stress and Inflammation of Placenta in Large White Pigs

The purpose of this study was to evaluate the impact of the backfat thickness of sows on reproductive performance and on lipid metabolism, oxidative stress, and inflammation. At farrowing, 60 sows were assigned to three groups: the low-backfat-thickness group (LBF, n = 20): sows' backfat thickness was between 9 and 12 mm; the medium-backfat-thickness group (MBF, n = 20): sows' backfat thickness was between 13 and 20 mm; and the high-backfat-thickness group (HBF, n = 20): sows' backfat thickness was between 21 and 25 mm. Maternal and fetal blood and placental samples were collected. Compared with the LBF and HBF groups, the MBF group delivered a significantly greater number of live piglets than the LBF or HBF groups. The different backfat thicknesses of sows had different effects on the lipid-related hormones and adipokines of maternal and fetal serum and placenta. Sows with poor or excessive backfat displayed higher levels of oxidative stress and higher levels of pro-inflammatory cytokines. According to these data, the thickness of a sow's backfat affects the characteristics of farrowing piglets and their lipid metabolism, as well as placental inflammation, maternal inflammation, and oxidative stress. A moderate backfat thickness (between 13 and 20 mm) was associated with greater reproductive performance in sows.