Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

2.3K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.3K
Changes in the Appendicular Skeleton with Age01:09

Changes in the Appendicular Skeleton with Age

2.2K
The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
2.2K
Bone Disorders01:29

Bone Disorders

3.9K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.9K
Aging01:26

Aging

172
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
172
Mitochondria01:37

Mitochondria

14.7K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
14.7K
Replicative Cell Senescence02:15

Replicative Cell Senescence

3.7K
Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
3.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Introduction to the special issue on the impact of climate change and air quality on human aging.

The journals of gerontology. Series A, Biological sciences and medical sciences·2026
Same author

Exceptionally low mortality despite widespread COVID-19 infection among Indigenous Tsimane and Moseten of Bolivia.

Social science & medicine (1982)·2026
Same author

Air pollution is linked to divergent cortical thickness patterns in brain regions vulnerable to Alzheimer's disease.

Neurotoxicology·2026
Same author

A need for pragmatism in preclinical aging and longevity research.

Nature aging·2026
Same author

In memoriam: Thomas Eugene Johnson.

GeroScience·2026
Same author

Sex-Specific Regulation of the Turandot Gene Family Modulates Temperature-Dependent Lifespan in Drosophila melanogaster.

Aging cell·2026

Related Experiment Video

Updated: Sep 6, 2025

Quantifying Tissue-Specific Proteostatic Decline in Caenorhabditis elegans
09:18

Quantifying Tissue-Specific Proteostatic Decline in Caenorhabditis elegans

Published on: September 7, 2021

3.0K

How ubiquitous is aging in vertebrates?

Steven N Austad1, Caleb E Finch2

  • 1University of Alabama at Birmingham, Birmingham, AL, USA.

Science (New York, N.Y.)
|June 23, 2022
PubMed
Summary

Some turtle species show minimal signs of aging, challenging common assumptions about senescence. These findings suggest unique aging processes in certain long-lived reptiles.

Area of Science:

  • Gerontology
  • Herpetology
  • Evolutionary Biology

Background:

  • Aging, or senescence, is a fundamental biological process characterized by progressive functional decline.
  • While common in many species, the rate and presence of aging can vary significantly, particularly in long-lived organisms.
  • Understanding aging variations across species provides insights into evolutionary trade-offs and biological mechanisms.

Purpose of the Study:

  • To investigate the presence and extent of aging in select long-lived turtle species.
  • To determine if these turtles exhibit characteristics typically associated with senescence.
  • To explore potential biological factors contributing to longevity and delayed aging in reptiles.

Main Methods:

  • Longitudinal studies tracking multiple health and physiological markers over extended periods.

More Related Videos

Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans
11:57

Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans

Published on: November 26, 2017

8.7K
Using Caenorhabditis elegans as a Model System to Study Protein Homeostasis in a Multicellular Organism
12:38

Using Caenorhabditis elegans as a Model System to Study Protein Homeostasis in a Multicellular Organism

Published on: December 18, 2013

6.2K

Related Experiment Videos

Last Updated: Sep 6, 2025

Quantifying Tissue-Specific Proteostatic Decline in Caenorhabditis elegans
09:18

Quantifying Tissue-Specific Proteostatic Decline in Caenorhabditis elegans

Published on: September 7, 2021

3.0K
Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans
11:57

Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans

Published on: November 26, 2017

8.7K
Using Caenorhabditis elegans as a Model System to Study Protein Homeostasis in a Multicellular Organism
12:38

Using Caenorhabditis elegans as a Model System to Study Protein Homeostasis in a Multicellular Organism

Published on: December 18, 2013

6.2K
  • Comparative analyses of age-related changes in various turtle populations.
  • Biomarker analysis to assess cellular and molecular indicators of aging.

    • Main Results:

    • Little to no evidence of increased mortality risk or functional decline with age was observed in the studied turtle populations.
    • Key physiological and molecular markers typically associated with aging remained stable across different age groups.
    • Some species exhibited negligible senescence, indicating a potential lack of biological aging within the study's timeframe.

    Conclusions:

    • Certain turtle species may possess biological mechanisms that significantly slow or halt the aging process.
    • These findings challenge the universality of typical senescence patterns and highlight the diversity of aging in the animal kingdom.
    • Further research is warranted to elucidate the specific genetic and physiological pathways responsible for negligible senescence in these reptiles.