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Updated: Sep 6, 2025

Microscale Vortex-assisted Electroporator for Sequential Molecular Delivery

Microscale Vortex-assisted Electroporator for Sequential Molecular Delivery

Published on: August 7, 2014

Recent Advances in Microscale Electroporation.

Sung-Eun Choi¹, Harrison Khoo¹, Soojung Claire Hur^1,2,3,4

¹Department of Mechanical Engineering, Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218, United States.

Chemical Reviews

|June 23, 2022

Summary

This summary is machine-generated.

Microscale electroporation (EP) enhances cell permeability for cargo delivery or membrane disruption. Microfluidic integration offers precise static or high-throughput continuous EP, improving cell assay sensitivity and therapeutic development.

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Last Updated: Sep 6, 2025

Microscale Vortex-assisted Electroporator for Sequential Molecular Delivery

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Published on: August 7, 2014

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Area of Science:

Biotechnology
Bioengineering
Cell Biology

Background:

Electroporation (EP) is a technique using electric fields to alter cell membrane permeability for cargo delivery or cell disruption.
Conventional macroscale EP faces limitations in precision and throughput.
Recent advancements have focused on microscale EP devices, often integrated with microfluidics.

Purpose of the Study:

To review the physical principles and design trends of microscale electroporation devices.
To discuss the applications of reversible and irreversible microscale EP.
To encourage the adoption of microscale EP technologies in scientific research and engineering.

Main Methods:

Review of physical principles governing microscale electroporation.
Analysis of design trends in static and continuous microfluidic EP devices.
Synthesis of current applications in therapeutics and intracellular analysis.

Main Results:

Microscale EP offers improved precision (static) and throughput (continuous) compared to macroscale methods.
Microscale EP is gentle on cells, enabling more sensitive cellular assays.
Advancements in microscale EP facilitate novel therapeutic development and intracellular content analysis.

Conclusions:

Microscale electroporation, particularly when integrated with microfluidics, represents a significant advancement over conventional methods.
These technologies provide enhanced control and efficiency for diverse biological applications.
Further exploration and implementation of microscale EP are encouraged for broader scientific and engineering impact.