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Updated: Sep 6, 2025
06:08
Pulse Wave Velocity Testing in the Baltimore Longitudinal Study of Aging
Published on: February 7, 2014
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Blood pressure variability: A potential marker of aging
Leonardo Bencivenga1, Philipe De Souto Barreto2, Yves Rolland2
1Department of Advanced Biomedical Sciences, University of Naples "Federico II", Italy; Gérontopôle de Toulouse, Institut du Vieillissement, CHU de Toulouse, France.
Ageing Research Reviews
|June 23, 2022
Summary
Increased Blood Pressure Variability (BPV) in aging is linked to organ damage and geriatric syndromes. This study explores BPV
Area of Science:
- Gerontology
- Cardiovascular Physiology
- Neuroscience
Background:
- Aging alters neuro-cardiovascular regulation, impairing physiological variability.
- Increased Blood Pressure Variability (BPV) correlates with organ damage and predicts adverse health outcomes.
- BPV may reflect aging-related homeostatic dysregulation and subclinical inflammation.
Purpose of the Study:
- To analyze the relationship between Blood Pressure Variability (BPV) and the pathophysiology of aging.
- To discuss the potential of BPV as a novel aging biomarker.
Main Methods:
- Review of existing literature on aging, BPV, and related molecular mechanisms.
- Analysis of shared pathways including inflammation, endothelial dysfunction, and oxidative stress.
- Exploration of links between BPV and hallmarks of aging.
Main Results:
- Aging and altered BPV share molecular mechanisms like subclinical inflammation, altered endothelial function, and reactive oxygen species (ROS) production.
- Arterial stiffness and autonomic dysfunction are associated with BPV impairment in the elderly.
- BPV connects to aging hallmarks: genomic instability, epigenetic modification, and mitochondrial damage.
Conclusions:
- BPV is intricately linked to the aging process and its underlying molecular changes.
- BPV may serve as a valuable indicator of biological aging.
- Further research into BPV as an aging marker is warranted.
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