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Identification of the Source of Secreted Proteins in the Kidney by Brefeldin A Injection
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A link between Krüppel-like factor 4, complement activation, and kidney damage

Diana Karpman1, Sebastian Loos2

  • 1Department of Pediatrics, Clinical Sciences Lund, Lund University, Lund, Sweden.

Kidney International
|June 23, 2022
PubMed

Krüppel-like factors (KLFs) are transcription factors with important roles in tissue homeostasis. KLF4 possesses antithrombotic and anti-inflammatory properties. In this issue, Estrada et al. show that endothelial KLF4 prevents complement deposition in glomeruli and in its absence the cell-bound complement regulator CD55 was reduced. The study included endothelial-specific KLF4 knockdown mice that mimic thrombotic microangiopathy and thrombotic microangiopathy patient biopsies showing decreased KLF4 and CD55. The results suggest that KLF4 is involved in the regulation of glomerular complement deposition.

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