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Related Concept Videos

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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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The eye is a spherical, hollow structure composed of three tissue layers. The outer layer — the fibrous tunic, comprises the sclera — a white structure — and the cornea, which is transparent. The sclera encompasses some of the ocular surface, most of which is not visible. However, the 'white of the eye' is distinctively visible in humans compared to other species. The cornea, a clear covering at the front of the eye, enables light penetration. The eye's middle...
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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Updated: Sep 6, 2025

Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
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Elucidating macular structure-function correlations in glaucoma.

Sara Giammaria1,2, Glen P Sharpe1, Oksana Dyachok1

  • 1Department of Ophthalmology and Visual Sciences, Dalhousie University and Nova Scotia Health Authority, 1276 South Park Street, Victoria Building, Room 2035, Halifax, NS, B3H 2Y9, Canada.

Scientific Reports
|June 23, 2022
PubMed
Summary
This summary is machine-generated.

Precise mapping of optical coherence tomography (OCT) to visual field (VF) testing did not improve structure-function correlations in glaucoma. Conventional mapping showed stronger correlations than localized mapping, suggesting variability and damage patterns are key factors.

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Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Neuroscience

Background:

  • Accurate correlation between structural (Optical Coherence Tomography, OCT) and functional (Visual Field, VF) data is crucial for diagnosing and monitoring eye diseases like glaucoma.
  • Current methods may suffer from suboptimal mapping between OCT measurement locations and VF stimuli, potentially weakening structure-function relationships.

Purpose of the Study:

  • To test if fundus-tracking perimetry, enabling precise mapping of OCT measurements to VF sensitivity, enhances structure-function correlations in the macula.
  • To compare the efficacy of a conventional mapped approach (CMA) versus a localized mapped approach (LMA) in achieving stronger structure-function correlations.

Main Methods:

  • 38 glaucoma patients and 10 healthy subjects underwent OCT imaging and VF testing.
  • A conventional 64-superpixel OCT grid was mapped to 40 VF units using standard automated perimetry (CMA).
  • A 144-superpixel OCT grid was mapped to 68 VF locations using fundus-tracking perimetry (LMA).

Main Results:

  • The conventional mapped approach (CMA) yielded significantly higher structure-function correlations compared to the localized mapped approach (LMA).
  • A small percentage of vectors fell within corresponding mapped OCT superpixels for both CMA (<20%) and LMA (<5%).
  • Most correlation vectors pointed towards areas of structural damage, irrespective of the mapping precision.

Conclusions:

  • Precise mapping of OCT measurements to VF sensitivity using fundus-tracking perimetry did not improve structure-function correlations in this study.
  • Measurement variability and the pattern of structural damage appear to be more influential on correlation strength than precise stimulus mapping.
  • Rethinking the interpretation of structure-function relationships in glaucoma, considering factors beyond precise spatial correlation, is warranted.