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Preparation of 1° Amines: Gabriel Synthesis

Preparation of 1° Amines: Gabriel Synthesis

Direct alkylation is not a suitable method for synthesizing amines because it produces polyalkylated products. Gabriel synthesis is the most preferred method to exclusively make primary amines. The method uses phthalimide, which contains a protected form of nitrogen that participates in alkylation only once to predominantly give primary amines.
Strong bases like NaOH or KOH deprotonate the phthalimide to form the corresponding anion, which acts as a nucleophile. Further, the anion attacks an...

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Related Experiment Video

Updated: Sep 6, 2025

Author Spotlight: Accelerating Discovery in Microporous Material Chemistry

Author Spotlight: Accelerating Discovery in Microporous Material Chemistry

Published on: October 6, 2023

Phase- and composition-controlled synthesis

Weiguang Yang¹, Jieun Yang², Hyeon Suk Shin³

¹Department of Chemistry and Low-Dimensional Carbon Materials Center, Ulsan National Institute of Science and Technology, Ulsan, Republic of Korea.

Nature Materials

|June 23, 2022

Summary

No abstract available in PubMed .

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