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Updated: Sep 6, 2025

Preparation of Binary and Ternary Deep Eutectic Systems

Preparation of Binary and Ternary Deep Eutectic Systems

Published on: October 31, 2019

Recent Developments on Ionic Liquids and Deep Eutectic Solvents for Drug Delivery Applications.

Idrees B Qader¹, Kamalesh Prasad^2,3

¹Pharmaceutical Chemistry Department, College of Pharmacy, Hawler Medical University, Erbil, Kurdistan Region, Iraq.

Pharmaceutical Research

|June 23, 2022

Summary

Ionic liquids (ILs) and deep eutectic solvents (DESs) show promise for advanced drug delivery systems, including slow and nanoscale applications. However, further research on long-term safety and clinical trials is needed before practical use.

Keywords:

deep eutectic solvents drug delivery ionic liquids pharmaceuticals

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Published on: December 20, 2016

Area of Science:

Pharmaceutical Sciences
Materials Science
Biomedical Research

Background:

Ionic liquids (ILs) and deep eutectic solvents (DESs) possess unique, tunable properties applicable across various scientific fields.
Their potential use in pharmaceutical formulations is gaining attention from formulation scientists.
Active pharmaceutical ingredients (APIs) can be combined with ILs and DESs for novel applications.

Purpose of the Study:

To discuss the concept of pharmaceutical ILs and DESs.
To explore the applications of these solvent systems in slow and nanoscale drug delivery.
To review existing literature and identify challenges for clinical translation.

Main Methods:

Literature review of published studies on ILs and DESs in drug delivery.
Discussion of the properties and potential of ILs and DESs as drug carriers.
Analysis of proof-of-concept studies regarding biological activity retention.

Main Results:

ILs and DESs demonstrate suitability for various drug delivery applications, including slow and nanoscale delivery.
Numerous combinations of ILs, DESs, and APIs have been explored in research settings.
Proof-of-concept studies show encouraging retention of biological activity in ionic forms.

Conclusions:

Pharmaceutical ILs and DESs hold significant potential for innovative drug delivery systems.
Despite promising results, no IL or DES-based slow drug delivery vehicles are currently in practical use.
Long-term toxicity data, safety evaluations, and clinical trials are essential for the future development and application of these systems in biomedical industries.