Related Experiment Video

Updated: Sep 6, 2025

Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using PolyI:C to Study Susceptibility and Resilience in Offspring
09:09

Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using PolyI:C to Study Susceptibility and Resilience in Offspring

Published on: August 17, 2022

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Association of juvenile idiopathic arthritis with maternal infection: a case control study

Anna Sutton1, Sabah M Quraishi2, Susan Shenoi3

  • 1Department of Epidemiology, University of Washington School of Public Health, UW Box # 351619, 3980 15th Ave NE, Seattle, WA, 98195, USA. asutton6@uw.edu.

Pediatric Rheumatology Online Journal
|June 23, 2022
PubMed

Insights

Maternal infection does not increase the risk of Juvenile Idiopathic Arthritis (JIA). Further research is needed to explore potential sex-specific differences in this association.

Area of Science:

  • Pediatric Rheumatology
  • Immunology
  • Epidemiology

Background:

  • Maternal infections are suspected risk factors for childhood autoimmune diseases.
  • Limited research exists on the link between maternal infection and Juvenile Idiopathic Arthritis (JIA).

Purpose of the Study:

  • To investigate the association between maternal infection during pregnancy and the development of Juvenile Idiopathic Arthritis (JIA) in offspring.

Main Methods:

  • A case-control study utilized a database of 1290 JIA cases and 6072 matched controls.
  • Maternal infection data were sourced from Washington State birth records.
  • Logistic regression analysis calculated adjusted odds ratios (ORs) and 95% confidence intervals (95% CIs).

Main Results:

  • No significant association was found between maternal infection and JIA (OR = 1.02, 95% CI: 0.8-1.3).
  • Specific JIA categories, including persistent oligoarticular, RF negative polyarticular, and enthesitis-related JIA, showed no association with maternal infection.
  • Sex-stratified analysis indicated a potential, though not statistically significant, increased association between maternal infection and JIA in females.

Conclusions:

  • The study did not find evidence that maternal infection increases the risk of Juvenile Idiopathic Arthritis (JIA).
  • Suggestive sex-specific differences warrant further investigation in larger cohorts.
Abstract

Keywords:
Juvenile arthritisPregnancyRisk factors

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