Changing Perspectives from Oxidative Stress to Redox Signaling-Extracellular Redox Control in Translational Medicine
Paola Loreto Palacio1, José R Godoy2, Orhan Aktas1
1Department of Neurology, Medical Faculty, Heinrich Heine University, Moorenstraße 5, 40225 Düsseldorf, Germany.
Antioxidants (Basel, Switzerland)
|June 24, 2022
Summary
Oxidative stress impacts major diseases, but redox modifications are vital for cell signaling. Understanding extracellular redox regulation offers new diagnostic and therapeutic strategies for health and disease.
Area of Science:
- Biochemistry
- Cell Biology
- Physiology
Background:
- Oxidative stress is implicated in numerous diseases.
- Redox modifications, including thiol switches, are critical for cellular signaling.
- Thioredoxin (Trx) family proteins and extracellular redox factors play essential physiological roles.
Purpose of the Study:
- To highlight the impact of extracellular redox regulation on health, disease, and intermediate pathophenotypes.
- To discuss recent advances in analyzing redox changes in body fluids.
- To explore translational strategies for novel preventive and diagnostic tools and treatments.
Main Methods:
- Review of current literature on oxidative stress and redox biochemistry.
- Analysis of the role of extracellular redox proteins and thiols in cell communication.
- Discussion of novel, non-invasive techniques for analyzing redox status in biological samples.
Main Results:
- Redox modifications are essential for physiological signal transduction.
- Extracellular redox regulation significantly influences health and disease states.
- New analytical methods enable accessible assessment of redox changes in body fluids.
Conclusions:
- Extracellular redox regulation is a key factor in health and disease.
- Advances in redox biochemistry facilitate the development of innovative medical tools.
- Translational research in redox biology holds promise for future diagnostics and therapeutics.
Keywords:
biomarkersextracellular redox regulationglutathioneoxidative stressreactive oxygen speciesthioredoxin proteinstranslational medicineMore Related Videos
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