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Updated: Sep 6, 2025
17:35
A Microplate Assay to Assess Chemical Effects on RBL-2H3 Mast Cell Degranulation: Effects of Triclosan without Use of an Organic Solvent
Published on: November 1, 2013
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Triclosan: A Small Molecule with Controversial Roles.
Maria Stefania Sinicropi1, Domenico Iacopetta1, Jessica Ceramella1
1Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Arcavacata di Rende, Italy.
Antibiotics (Basel, Switzerland)
|June 24, 2022
Summary
Triclosan (TCS), an antimicrobial, is widely used but potentially harmful. This review examines the pros and cons of TCS use in humans, considering its environmental presence and debated toxicity.
Area of Science:
- Environmental Science
- Toxicology
- Pharmacology
Background:
- Triclosan (TCS) is a broad-spectrum antimicrobial found in many consumer and medical products.
- Its widespread use leads to environmental ubiquity and potential bioaccumulation due to lipophilicity.
- TCS is classified as an endocrine disrupting chemical (EDC), raising health concerns.
Purpose of the Study:
- To review the advantages and disadvantages of triclosan (TCS) use in humans.
- To assess the current understanding of TCS toxicity and its long-term effects.
- To inform whether the use of TCS is advisable.
Main Methods:
- Literature review of existing studies on triclosan (TCS).
- Analysis of reports on TCS toxicity, environmental presence, and potential health impacts.
- Examination of regulatory actions and emerging therapeutic applications of TCS.
Main Results:
- TCS is effective in products like toothpaste for oral health.
- Concerns exist regarding its endocrine-disrupting potential and environmental persistence.
- Regulatory bodies have restricted its use in certain products, but its application in others continues.
Conclusions:
- The overall risk-benefit profile of triclosan (TCS) remains debated.
- Further research is needed to clarify the long-term effects of low-concentration TCS exposure in mammals.
- Emerging research suggests potential therapeutic uses for TCS, warranting careful consideration.
Keywords:
Colgate Total®TCSantimicrobialsendocrine disrupting chemicalspersonal care productstoxicitytriclosanMore Related Videos
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