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Updated: Sep 6, 2025

Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome
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Published on: June 15, 2016

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Dysregulation of Small Nucleolar RNAs in B-Cell Malignancies

Martijn W C Verbeek1, Stefan J Erkeland1, Vincent H J van der Velden1

  • 1Department of Immunology, Erasmus MC, University Medical Center Rotterdam, Doctor Molewaterplein 40, 3015 GD Rotterdam, The Netherlands.

Biomedicines
|June 24, 2022
PubMed

Insights

Small nucleolar RNAs (snoRNAs) are crucial for B-cell development and function. Dysregulated snoRNA expression is linked to various B-cell cancers, offering potential for new diagnostic and therapeutic strategies.

Area of Science:

  • Molecular Biology
  • Oncology
  • Immunology

Background:

  • Small nucleolar RNAs (snoRNAs) regulate RNA modifications, impacting mRNA splicing and protein translation.
  • Aberrant snoRNA expression is implicated in human cancer development and progression.
  • This review specifically examines snoRNAs in the context of normal and malignant B-cell development.

Purpose of the Study:

  • To review the role of snoRNAs in normal B-cell differentiation.
  • To explore the dysregulation of snoRNAs in various B-cell malignancies.
  • To discuss the potential of snoRNAs as diagnostic biomarkers or therapeutic targets in B-cell cancers.

Main Methods:

  • Literature review focusing on snoRNAs in B-cell development and malignancies.
  • Analysis of studies reporting snoRNA dysregulation in B-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, B-cell non-Hodgkin's lymphoma, and plasma cell neoplasms.
  • Examination of the association between snoRNA expression, molecular subgroups, and clinical outcomes.

Main Results:

  • SnoRNA activity is essential for normal B-cell differentiation.
  • Dysregulated snoRNA expression is a hallmark of multiple B-cell malignancies.
  • SnoRNA expression patterns correlate with cytogenetic/molecular subgroups and patient prognosis.
  • Translocations involving snoRNAs have been identified in B-cell cancers.

Conclusions:

  • SnoRNAs play a critical role in both normal and malignant B-cell development.
  • Altered snoRNA expression contributes to oncogenic transformation in B-cell malignancies.
  • Targeting snoRNAs presents a promising avenue for novel diagnostic biomarkers and therapeutic interventions in B-cell cancers.
Keywords:
B-cell non-Hodgkin’s lymphomaB-cellsacute lymphoblastic leukemiachronic lymphocytic leukemiamultiple myelomasmall non-coding RNAsmall nucleolar RNAsnoRNA

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