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Histone Demethylase JMJD2D: A Novel Player in Colorectal and Hepatocellular Cancers

Qiang Chen1,2, Kesong Peng3, Pingli Mo1

  • 1State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Biology, School of Life Sciences, Xiamen University, Xiamen 361102, China.

Cancers
|June 24, 2022
PubMed

Insights

Histone demethylase JMJD2D (KDM4D) drives colorectal and liver cancer progression by regulating key oncogenic pathways. Targeting JMJD2D shows promise for cancer therapy and enhancing immunotherapy effectiveness.

Area of Science:

  • Epigenetics
  • Molecular Oncology

Background:

  • Posttranslational modifications (PTMs) of histones are crucial in biological functions and tumorigenesis.
  • Histone demethylase JMJD2D (KDM4D) antagonizes H3K9 methylation, promoting gene transcription and acting as an epigenetic factor in DNA repair, replication, and cell cycle regulation.

Purpose of the Study:

  • To review the molecular mechanisms by which JMJD2D promotes colorectal cancer (CRC) and hepatocellular cancer (HCC) progression.
  • To summarize the potential of JMJD2D targeting inhibitors in cancer suppression and immunotherapy enhancement.

Main Methods:

  • Literature review of molecular mechanisms and therapeutic strategies.
  • Analysis of JMJD2D's role as a coactivator or antagonist in cancer-related signaling pathways.

Main Results:

  • JMJD2D is recognized for its oncogenic role in CRC and HCC.
  • JMJD2D coactivates key signaling molecules (e.g., β-catenin, Gli1/2, HIF1α, STAT3) and antagonizes p53, driving cancer progression.

Conclusions:

  • JMJD2D is a significant driver of CRC and HCC.
  • Targeting JMJD2D offers a potential therapeutic strategy for these cancers and can synergize with anti-PD-1/PD-L1 immunotherapy.
Keywords:
H3K9me3JMJD2DKDM4Dcolorectal cancerepigenetichepatocellular cancer

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