Related Experiment Video

Updated: Sep 6, 2025

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
14:39

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

32.0K

Application of a Cold Dry Air Provocation Test in Pediatric Patients with Asthma

Ji Young Ahn1, Bong Seok Choi2

  • 1Department of Pediatrics, College of Medicine, Yeungnam University, Daegu 42415, Korea.

Children (Basel, Switzerland)
|June 24, 2022
PubMed

Insights

The cold dry air (CDA) provocation test effectively identifies non-eosinophilic asthma in children. This test shows potential for assessing asthma severity by measuring airway hyperreactivity to non-specific stimuli.

Area of Science:

  • Pediatric Pulmonology
  • Allergy and Immunology
  • Respiratory Medicine

Background:

  • Asthma is a chronic airway inflammatory disease marked by reversible obstruction and hyperreactivity.
  • Current diagnostic methods may not fully capture all asthma phenotypes, particularly non-eosinophilic asthma.
  • The cold dry air (CDA) provocation test is a novel method to assess airway hyperreactivity.

Purpose of the Study:

  • To evaluate the utility of the CDA provocation test in diagnosing asthma in pediatric patients.
  • To investigate the correlation between CDA test results and asthma phenotypes, specifically eosinophilic versus non-eosinophilic asthma.
  • To explore the relationship between CDA test parameters and other markers of asthma severity and control.

Main Methods:

  • Seventy-two children and adolescents (age > 5 years) with chronic cough, shortness of breath, and wheezing were enrolled.
  • Standard allergy, pulmonary function, methacholine provocation, and CDA provocation tests were performed.
  • Key CDA parameters measured included FEV1 changes post-provocation (CDA5 dFEV1, CDA15 dFEV1) and provocation time to a 10% FEV1 decrease (PT10).

Main Results:

  • Out of 72 subjects, 51 were diagnosed with asthma.
  • A positive CDA test correlated significantly with non-eosinophilic asthma.
  • Patients with a positive CDA test exhibited lower sputum eosinophil and eosinophil cationic protein (ECP) levels.
  • CDA parameters (CDA5 dFEV1, CDA15 dFEV1, PT10) showed correlations with measures of airway hyperreactivity (PC20), allergic markers (total IgE), and inflammatory markers (sputum eosinophils, ECP).
  • Shorter PT10 correlated with decreased lung function parameters (FVC, FEV1, FEV1/FVC, FEF25-75) and lower peripheral blood eosinophil counts.

Conclusions:

  • The CDA provocation test demonstrates effectiveness in identifying airway hyperreactivity to non-specific stimuli in pediatric asthma.
  • The test shows a strong association with non-eosinophilic asthma, offering a potential diagnostic tool for this phenotype.
  • CDA test parameters, particularly PT10, may provide a means to assess asthma severity in children.

Keywords:
asthmachildchronic inflammatory airway diseasecold dry air provocation

More Related Videos

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber08:47

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Published on: March 3, 2023

2.5K
A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice09:58

A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice

Published on: April 13, 2010

22.6K

Related Concept Videos

Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
2.6K
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
2.8K
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
562
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
2.8K
Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
2.6K
COPD: Management Using Bronchodilators and Corticosteroids01:26

COPD: Management Using Bronchodilators and Corticosteroids

Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
292