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CASP1 Gene Polymorphisms and BAT1-NFKBIL-LTA-CASP1 Gene-Gene Interactions Are Associated with Restenosis after
Gilberto Vargas-Alarcón1, Julian Ramírez-Bello2, Marco Antonio Peña-Duque3
1Department of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, Mexico.
Biomolecules
|June 24, 2022
Summary
Specific single nucleotide polymorphisms (SNPs) in CASP1 and their interactions with BAT1, NFKBIL1, and LTA genes increase restenosis risk after coronary stenting.
Area of Science:
- Genetics
- Cardiovascular Medicine
- Molecular Biology
Background:
- Restenosis after coronary stenting remains a significant clinical challenge.
- Genetic factors are implicated in the development of post-stenting restenosis.
- Understanding the genetic basis can lead to improved risk stratification and prevention strategies.
Purpose of the Study:
- To investigate the association of specific single nucleotide polymorphisms (SNPs) in BAT1, NFKBIL1, LTA, and CASP1 genes with restenosis risk.
- To explore potential gene-gene interactions among these SNPs in relation to restenosis after coronary stenting.
Main Methods:
- Genotyping of BAT1 (rs2239527), NFKBIL1 (rs2071592), LTA (rs1800683), and CASP1 (rs501192, rs580253) SNPs was performed using TaqMan assays.
- A cohort of 219 patients (66 with restenosis, 153 without) undergoing coronary stenting was analyzed.
- Statistical models, including recessive, additive, and gene-gene interaction analyses, were employed.
Main Results:
- Polymorphisms rs2239527 (BAT1), rs2071592 (NFKBIL1), and rs1800683 (LTA) showed no significant association with restenosis risk.
- The AA genotype of CASP1 rs501192 A/G was associated with increased restenosis risk under recessive and additive models (OR=2.73, p=0.031; OR=1.65, p=0.039).
- The AA genotype of CASP1 rs580253 A/G significantly increased restenosis risk across multiple models (e.g., OR=5.38, p=0.003).
- A significant gene-gene interaction among BAT1-NFKBIL1-LTA-CASP1 was identified, strongly associated with restenosis susceptibility (OR=9.92, p<0.001).
Conclusions:
- Specific CASP1 gene polymorphisms (rs501192 and rs580253) are associated with an elevated risk of restenosis after coronary stenting.
- Gene-gene interactions involving BAT1, NFKBIL1, LTA, and CASP1 play a crucial role in restenosis susceptibility.
- These genetic markers may aid in identifying individuals at higher risk for post-stenting restenosis.
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