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Inflammatory and Cardiac Biomarkers in Relation with Post-Acute COVID-19 and Mortality: What We Know after Successive

Catalina Lionte1,2, Victorita Sorodoc1,2, Raluca Ecaterina Haliga1,2

  • 1Internal Medicine Department, "Grigore T. Popa" University of Medicine and Pharmacy Iasi, 700115 Iasi, Romania.

Diagnostics (Basel, Switzerland)
|June 24, 2022
PubMed

Insights

Inflammation and cardiac biomarkers like NT-pro BNP predict post-acute COVID-19 and 30-day mortality in noncritically ill patients. These markers offer valuable prognostic insights during successive pandemic waves.

Area of Science:

  • Biomedical research
  • Clinical diagnostics
  • Infectious disease epidemiology

Background:

  • Existing biomarkers correlate with mortality in critically ill COVID-19 patients.
  • No prediction tools are available for noncritically ill COVID-19 patients.
  • The prognostic value of inflammation and cardiac biomarkers needs evaluation for post-acute COVID-19 and 30-day mortality in noncritically ill patients.

Purpose of the Study:

  • To compare the independent prognostic value of inflammation and cardiac biomarkers.
  • To assess their predictive capability for post-acute COVID-19.
  • To evaluate their association with 30-day mortality in noncritically ill COVID-19 patients.

Main Methods:

  • Observational cohort study conducted in an emergency clinical hospital (October 2020 - December 2021).
  • Inclusion of consecutive patients with biomarkers measured within 24 hours of presentation.
  • Follow-up of patients for at least 30 days post-discharge.

Main Results:

  • Post-acute COVID-19 occurred in 20.3% of patients; 30-day mortality was 35.1% among 978 patients.
  • Neutrophil-to-lymphocyte ratio and NT-pro BNP correlated with 30-day mortality.
  • Monocyte-to-lymphocyte ratio and NT-pro BNP correlated with post-acute COVID-19; NT-pro BNP independently predicted 30-day mortality.

Conclusions:

  • Inflammation and cardiac biomarkers predict post-acute COVID-19 and 30-day mortality in hospitalized noncritically ill COVID-19 patients.
  • These biomarkers hold prognostic value across successive pandemic waves.
  • NT-pro BNP demonstrated independent predictive value for 30-day mortality.
Abstract

Keywords:
30-day mortalityNT-pro BNPhigh sensitivity cardiac troponininflammatory biomarkerspost-acute COVID-19variants of concern

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