Related Experiment Video
Updated: Sep 6, 2025
Resting-State Connectivity and Neuroimaging of Prefrontal Cortex Activity During a Block-Design Yoga Asana Practice Using fNIRS
Published on: June 24, 2025
Resting-State Neuronal Activity and Functional Connectivity Changes in the Visual Cortex after High Altitude
Xinjuan Zhang1, Taishan Kang2, Yanqiu Liu1
1Institute of Brain Diseases and Cognition, School of Medicine, Xiamen University, Xiamen 361102, China.
High altitude exposure alters brain activity and connectivity. Hypoxia/reoxygenation impacts visual cortex function, affecting neuronal connections and motor cortex integration.
Area of Science:
- Neuroscience
- Altitude Medicine
- Physiology
Background:
- Visual cortex damage from high altitude is known.
- Neuronal activity and functional connectivity (FC) changes post-hypoxia/reoxygenation are unclear.
Purpose of the Study:
- Investigate hematological, behavioral, and brain activity changes after high altitude exposure.
- Clarify visual cortex neuronal activity and FC alterations due to hypoxia/reoxygenation.
Main Methods:
- 23 students exposed to 4300m for 30 days.
- Magnetic resonance imaging (MRI) scans, blood tests, and visual behavior tests conducted at baseline, 7 days, and 3 months post-exposure.
- Analysis of hematological parameters, spontaneous brain activity (ALFF, ReHo, VMHC), and FC.
Main Results:
- Hematological parameters (hematocrit, hemoglobin, RBC) increased post-exposure.
- Increased amplitudes of low-frequency fluctuations (ALFF) in visual and motor cortices.
- Altered regional homogeneity (ReHo) and voxel-mirrored homotopic connectivity (VMHC) observed.
- Decreased FC between visual (lingual gyrus) and motor (postcentral gyrus) cortices.
- Color accuracy correlated with ALFF and ReHo.
Conclusions:
- Hypoxia/reoxygenation significantly impacts hematological and brain activity markers.
- Altered FC suggests increased visual-motor cortex integration but decreased specific pathway connectivity.
- Findings provide insights into neurological adaptations to high altitude environments.
More Related Videos
12:29Coherence between Brain Cortical Function and Neurocognitive Performance during Changed Gravity Conditions
Published on: May 23, 2011
10:43Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity
Published on: July 1, 2014