The Role of Non-Coding RNAs in Kidney Diseases
Laurent Metzinger1, Juan Antonio Moreno2,3,4, Valérie Metzinger-Le Meuth1,5
1HEMATIM UR 4666, C.U.R.S, Université de Picardie Jules Verne, CEDEX 1, 80025 Amiens, France.
International Journal of Molecular Sciences
|June 24, 2022
Summary
Renal diseases encompass various conditions like acute kidney injury and chronic kidney disease. Understanding these kidney pathologies is crucial for effective treatment and management.
Area of Science:
- Nephrology
- Internal Medicine
- Pathology
Background:
- Renal diseases represent a broad spectrum of kidney pathologies.
- Conditions include acute kidney injury (AKI), chronic kidney disease (CKD), end-stage renal disease (ESRD), diabetic nephropathy (DN), kidney cancer, and polycystic kidney disease.
Discussion:
- The diversity of renal diseases necessitates tailored diagnostic and therapeutic approaches.
- Early detection and intervention are key to managing kidney disease progression.
Key Insights:
- AKI and CKD are common forms of kidney disease with distinct underlying mechanisms.
- Diabetic nephropathy highlights the link between metabolic disorders and kidney damage.
- Kidney cancer and polycystic kidney disease present unique clinical challenges.
Outlook:
- Further research into the molecular mechanisms of renal diseases can lead to novel treatments.
- Improved screening protocols can enhance the early diagnosis of various kidney pathologies.
- Integrated care models are essential for managing patients with complex renal conditions.
Related Concept Videos
01:10Nephrons
3.4K
The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
3.4K
02:39lncRNA - Long Non-coding RNAs
8.9K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.9K
01:20Types of RNA
6.2K
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
RNA Performs Diverse...
6.2K
01:20Renal Corpuscle
3.2K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
3.2K
01:25Chronic Kidney Disease I: Introduction
65
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
65
01:30Acute Kidney Injury IV: Diagnostic Studies and Prevention
56
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
56