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The Affective Dimension of Pain Appears to Be Determinant within a Pain-Insomnia-Anxiety Pathological Loop in

Lliure-Naima Mory1,2, Daniel de Oliveira Fernandes1, Christian Mancini1

  • 1Neurology Unit, Medicine Section, Department of Neuroscience and Movement Science, Faculty of Science and Medicine, University of Fribourg, 1700 Fribourg, Switzerland.

Journal of Clinical Medicine
|June 24, 2022
PubMed
Abstract

Insights

Fibromyalgia patients experience a loop between affective pain, anxiety, and insomnia. High pain amplifies this cycle, involving depression and sensory pain, impacting disease pathology.

Area of Science:

  • Neuroscience
  • Pain Research
  • Psychiatry

Background:

  • Fibromyalgia (FM) is a complex chronic pain condition.
  • Interactions between FM symptoms like pain, sleep, and mood are not fully understood.
  • Distinguishing sensory and affective pain dimensions is crucial for understanding FM pathology.

Purpose of the Study:

  • To investigate the interplay between pain, sleep, and mood disorders in fibromyalgia.
  • To differentiate the influence of sensory and affective pain dimensions on FM symptoms.
  • To identify potential pathological loops contributing to fibromyalgia.

Main Methods:

  • Evaluated 16 female fibromyalgia patients and 11 healthy controls.
  • Assessed pain, mood (anxiety, depression), and sleep disorders.
  • Utilized analysis of variance and correlation analyses to examine symptom interactions.

Main Results:

  • Fibromyalgia patients reported widespread pain with similar sensory and affective components.
  • Patients exhibited moderate anxiety, depression, and insomnia compared to controls.
  • Affective pain, but not sensory pain or intensity, correlated with anxiety and insomnia, forming a loop. High pain amplified this loop, including depression and sensory pain.

Conclusions:

  • A pathological loop involving affective pain, insomnia, and anxiety was identified in fibromyalgia.
  • High ongoing pain exacerbates the interaction between these core FM symptoms.
  • Understanding these symptom interplays offers insights into FM determinants and potential therapeutic targets.
Keywords:
affective painanxietyfibromyalgiainsomniaongoing pain

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