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Evaluation of Atopic Dermatitis and Cutaneous Infectious Disorders Using Sequential Pattern Mining: A Nationwide
Ju-Hee Han1, Jae-Woong Yoon2, Hwa-Jung Yook1
1Department of Dermatology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.
Journal of Clinical Medicine
|June 24, 2022
Summary
Patients with atopic dermatitis (AD) face a higher risk of skin infections like molluscum contagiosum and impetigo. Early detection and management of these infections are crucial for preventing AD worsening.
Area of Science:
- Dermatology
- Epidemiology
- Infectious Diseases
Background:
- Atopic dermatitis (AD) is linked to increased susceptibility to cutaneous infections due to impaired skin barrier and immune dysfunction.
- Previous research suggests a connection between AD and skin infections, but real-world data on specific associations and onset patterns are limited.
Purpose of the Study:
- To investigate the association between atopic dermatitis and various cutaneous infectious disorders using real-world data.
- To identify specific infectious comorbidities and their onset durations in patients with AD through sequential pattern mining (SPM).
Main Methods:
- Analysis of National Health Insurance data from 2010-2013.
- Application of sequential pattern mining (SPM) to identify comorbid infectious diseases and their temporal relationships with AD.
Main Results:
- Patients with AD exhibited significantly higher risks for molluscum contagiosum (aOR, 5.273), impetigo (aOR, 2.852), chickenpox (aOR, 2.251), otitis media (aOR, 1.748), eczema herpeticum (aOR, 1.292), and viral warts (aOR, 1.105).
- Molluscum contagiosum showed the highest comorbidity (1.06%) and the shortest onset duration (77.42 days) among the identified associations.
Conclusions:
- Atopic dermatitis is associated with an elevated risk of developing cutaneous infectious disorders.
- Particular attention should be given to the strong associations with impetigo, molluscum contagiosum, and otitis media to aid in preventing AD exacerbation.
