Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

X-linked dilated cardiomyopathy.

B A Berko, M Swift

The New England Journal of Medicine

|May 7, 1987

Summary

This summary is machine-generated.

This study suggests X-linked inheritance of idiopathic dilated cardiomyopathy, with early onset in males and late onset in females. This pattern indicates a potential genetic basis for the condition in this family.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A model for research training in a child psychiatry residency : process and outcome.

Academic psychiatry : the journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry·2014

Same author

Three-dimensional structure of Bax-mediated pores in membrane bilayers.

Cell death & disease·2013

Same author

Changing pattern of clinical illness in children with group A streptococcal bacteremia.

The Canadian journal of infectious diseases = Journal canadien des maladies infectieuses·2012

Same author

Observation of two-neutrino double-beta decay in 136Xe with the EXO-200 detector.

Physical review letters·2011

Same author

A magnetically driven piston pump for ultra-clean applications.

The Review of scientific instruments·2011

Same author

Towards a Personal Health Management Assistant.

Journal of biomedical informatics·2010

Same journal

Ebola at 50 - Lessons for Outbreak Response and Preparedness.

The New England journal of medicine·2026

Same journal

Ianalumab plus Eltrombopag in Immune Thrombocytopenia. Reply.

The New England journal of medicine·2026

Same journal

Ianalumab plus Eltrombopag in Immune Thrombocytopenia.

The New England journal of medicine·2026

Same journal

Hypertension Control in Low-Income Patients. Reply.

The New England journal of medicine·2026

Same journal

Hypertension Control in Low-Income Patients.

The New England journal of medicine·2026

Same journal

Hypertension Control in Low-Income Patients.

The New England journal of medicine·2026

See all related articles

Area of Science:

Genetics
Cardiology
Human Inheritance

Background:

Idiopathic dilated cardiomyopathy (IDCM) is a significant cause of heart failure.
Understanding the genetic basis of IDCM is crucial for diagnosis and treatment.
Previous studies have identified various genetic mutations associated with familial forms of cardiomyopathy.

Observation:

A large kindred with 11 male members exhibiting signs of IDCM was investigated.
Affected males presented with early-onset symptoms (ages 15-21) and a poor prognosis.
Mothers of affected males displayed late-onset dilated cardiomyopathy (in their 40s) with gradual heart failure progression.

Findings:

The pattern of early-onset in males, late-onset in females, and absence of male-to-male transmission strongly suggests X-linked inheritance of IDCM.

Related Experiment Videos

The later onset in female carriers is consistent with X-inactivation and heterozygosity for the causative allele.

This family's data provides compelling evidence for a specific X-linked genetic locus responsible for IDCM.

Implications:

Identifying the specific gene involved in this X-linked IDCM could lead to targeted therapies.
This finding may help in genetic counseling for families with a history of cardiomyopathy.
It suggests that some sporadic cases of IDCM may result from new mutations at this X-linked locus.