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Role of Yes-Associated Protein in Psoriasis and Skin Tumor Pathogenesis

Jinjing Jia1,2,3, Yuqian Wang4, Xiumei Mo1,2,3

  • 1State Key Laboratory of Dampness Syndrome of Chinese Medicine, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510120, China.

Journal of Personalized Medicine
|June 24, 2022
PubMed

Insights

Yes-associated protein (YAP) is implicated in psoriasis and skin tumors. Increased YAP expression suggests its role in skin disease pathogenesis, offering potential targets for new treatments.

Area of Science:

  • Dermatology
  • Molecular Biology
  • Oncology

Background:

  • Psoriasis and skin tumors are chronic conditions with unknown causes and limited treatments.
  • Understanding disease pathogenesis is crucial for developing targeted therapies.
  • The Hippo signaling pathway, particularly Yes-associated protein (YAP), is a potential key player.

Purpose of the Study:

  • To review literature on YAP-associated disease mechanisms in psoriasis and skin tumors.
  • To discuss the latest research on YAP's role in these conditions.
  • To explore YAP as a potential therapeutic target for skin diseases.

Main Methods:

  • Literature review of studies investigating YAP in psoriasis and skin tumors.
  • Analysis of YAP's known functions in cell regulation (apoptosis, proliferation, differentiation, angiogenesis).
  • Examination of YAP expression levels in affected skin tissues.

Main Results:

  • YAP regulates critical cellular processes including apoptosis, proliferation, differentiation, and angiogenesis.
  • YAP plays a role in maintaining skin's three-dimensional structure.
  • Studies show elevated YAP expression in both psoriasis and skin tumors.

Conclusions:

  • Increased YAP expression in psoriasis and skin tumors suggests a significant role in disease pathogenesis.
  • YAP's functions in cell regulation and its overexpression link it to skin inflammation and malignancies.
  • Targeting YAP presents a promising avenue for novel therapeutic strategies in dermatology and oncology.
Keywords:
Hippo signaling pathwayYes-associated proteincutaneous squamous cell carcinomamelanomapsoriasisskin tumors

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