Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

3.0K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
3.0K
COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

501
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
501
Chronic Obstructive Pulmonary Disease-I: Introduction01:20

Chronic Obstructive Pulmonary Disease-I: Introduction

2.9K
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
2.9K
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

357
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
357
Chronic Obstructive Pulmonary Disease01:22

Chronic Obstructive Pulmonary Disease

1.4K
COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
1.4K
Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.01:25

Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.

2.9K
Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
2.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pulmonary Function Decline in Alpha-1 Antitrypsin Deficiency: A Systematic Review and Meta-Analysis.

International journal of chronic obstructive pulmonary disease·2026
Same author

The Emerging Role of the Cancerous Inhibitor of Protein Phosphatase 2A in Pulmonary Diseases.

Medicina (Kaunas, Lithuania)·2025
Same author

Soft, stretchable conductive hydrogels for high-performance electronic implants.

Science advances·2025
Same author

Damage sensing through TLR9 regulates inflammatory and antiviral responses during influenza infection.

Mucosal immunology·2025
Same author

Genesis of concurrent diseases: do diabetes mellitus and idiopathic pulmonary fibrosis have a direct relationship?

Thorax·2025
Same author

Debunking a mythology: Atelectasis is not a cause of postoperative fever.

Clinical imaging·2024

Related Experiment Video

Updated: Sep 6, 2025

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure
08:17

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure

Published on: August 25, 2017

11.1K

Senescence: Pathogenic Driver in Chronic Obstructive Pulmonary Disease.

Melissa Rivas1, Gayatri Gupta2, Louis Costanzo1

  • 1Department of Medicine, State University of New York Downstate Medical Centre, Brooklyn, NY 11203, USA.

Medicina (Kaunas, Lithuania)
|June 24, 2022
PubMed
Summary

Chronic obstructive pulmonary disease (COPD) involves accelerated lung aging due to cellular senescence. This review explores how senescent cells contribute to COPD pathology and potential therapies targeting this aging process.

Keywords:
agingchronic obstructive pulmonary diseasecigarette smokesenescence

More Related Videos

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence
13:59

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence

Published on: August 12, 2018

8.2K
Long Term Chronic Pseudomonas aeruginosa Airway Infection in Mice
15:43

Long Term Chronic Pseudomonas aeruginosa Airway Infection in Mice

Published on: March 17, 2014

22.9K

Related Experiment Videos

Last Updated: Sep 6, 2025

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure
08:17

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure

Published on: August 25, 2017

11.1K
A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence
13:59

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence

Published on: August 12, 2018

8.2K
Long Term Chronic Pseudomonas aeruginosa Airway Infection in Mice
15:43

Long Term Chronic Pseudomonas aeruginosa Airway Infection in Mice

Published on: March 17, 2014

22.9K

Area of Science:

  • Pulmonary Medicine
  • Cellular Biology
  • Aging Research

Background:

  • Chronic obstructive pulmonary disease (COPD) is characterized by accelerated lung aging.
  • Cellular senescence, marked by the senescence-associated secretory phenotype (SASP), accumulates in COPD lungs.
  • This accumulation impairs tissue repair and promotes inflammation.

Purpose of the Study:

  • To review the mechanisms linking cellular senescence to COPD.
  • To discuss the pathological consequences of senescence in COPD.
  • To explore therapeutic strategies targeting senescence in COPD.

Main Methods:

  • Literature review of studies on cellular senescence and COPD.
  • Analysis of evidence linking senescence markers to COPD pathogenesis.
  • Synthesis of current research on SASP in COPD.

Main Results:

  • Cellular senescence, driven by telomere dysfunction, DNA damage, and oxidative stress, is a key factor in COPD.
  • The SASP exacerbates lung inflammation and tissue damage in COPD patients.
  • Targeting senescence pathways presents a promising therapeutic avenue for COPD.

Conclusions:

  • Cellular senescence significantly contributes to COPD development and progression.
  • Understanding the role of SASP is crucial for COPD treatment.
  • Therapies aimed at senescent cells may offer new hope for COPD management.