Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Metal-Ligand Bonds02:51

Metal-Ligand Bonds

21.4K
The hemoglobin in the blood, the chlorophyll in green plants, vitamin B-12, and the catalyst used in the manufacture of polyethylene all contain coordination compounds. Ions of the metals, especially the transition metals, are likely to form complexes.
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
21.4K
Structural Isomerism02:34

Structural Isomerism

19.7K
Isomerism in Complexes
Isomers are different chemical species that have the same chemical formula. Structural isomerism of coordination compounds can be divided into two subcategories, the linkage isomers and coordination-sphere isomers.
Linkage isomers occur when the coordination compound contains a ligand that can bind to the transition metal center through two different atoms. For example, the CN− ligand can bind through the carbon atom or through the nitrogen atom. Similarly, SCN− can...
19.7K
EDTA: Chemistry and Properties01:22

EDTA: Chemistry and Properties

2.2K
Polydentate ligands are most widely used in complexometric titrations because they form more stable complexes with the metal ions than mono- or bidentate ligands due to the chelate effect. Examples of polydentate ligands are ethylenediaminetetraacetic acid (EDTA), crown ethers, and cryptands. The most important feature of optimal polydentate ligands is the ability to form 1:1 complexes in a single-step process. Amino carboxylic acid derivatives are frequently used as complexing agents. EDTA is...
2.2K
Colors and Magnetism03:02

Colors and Magnetism

12.3K
Color in Coordination Complexes
When atoms or molecules absorb light at the proper frequency, their electrons are excited to higher-energy orbitals. For many main group atoms and molecules, the absorbed photons are in the ultraviolet range of the electromagnetic spectrum, which cannot be detected by the human eye. For coordination compounds, the energy difference between the d orbitals often allows photons in the visible range to be absorbed and emitted, which is seen as colors by the human...
12.3K
Stereoisomerism02:52

Stereoisomerism

12.4K
Isomerism in Complexes
Isomers are different chemical species that have the same chemical formula.
Transition metal complexes often exist as geometric isomers, in which the same atoms are connected through the same types of bonds but with differences in their orientation in space. Coordination complexes with two different ligands in the cis and trans positions from a ligand of interest form isomers. For example, the octahedral [Co(NH3)4Cl2]+ ion has two isomers (Figure 1) In the cis...
12.4K
Complexation Equilibria: The Chelate Effect01:19

Complexation Equilibria: The Chelate Effect

645
In complexation reactions, metal atoms or cations interact with ligands to form donor-acceptor adducts called metal complexes. Ligands that bind through one donor site are monodentate, ligands with two donor sites are bidentate, and those with more than two donor sites are polydentate ligands. For example, ethylene diamine is a bidentate ligand that binds through two nitrogen donor atoms, forming a five-membered ring. EDTA is a polydentate ligand that binds through four oxygen and two nitrogen...
645

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction to "Strain Release Cycloadditions of 2H-Azirines: Access to Polycyclic Heterocycles".

Organic letters·2026
Same author

Cytochrome P450 Induction through the Efficient Photoinduced Release of a Pyridine-Substituted Agent from Ru(II).

Journal of the American Chemical Society·2025
Same author

Strain Release Cycloadditions of 2H-Azirines: Access to Polycyclic Heterocycles.

Organic letters·2025
Same author

TPDYs: strained macrocyclic diynes for bioconjugation processes.

Chemical communications (Cambridge, England)·2024
Same author

Tuning Co-Operative Energy Transfer in Copper(I) Complexes Using Two-Photon Absorbing Diimine-Based Ligand Sensitizers.

Angewandte Chemie (International ed. in English)·2024
Same author

Mixed Ru(II)-Ir(III) Complexes as Photoactive Inhibitors of the Major Human Drug Metabolizing Enzyme CYP3A4.

Inorganic chemistry·2024

Related Experiment Video

Updated: Sep 6, 2025

Preparation of SNS CobaltII Pincer Model Complexes of Liver Alcohol Dehydrogenase
06:31

Preparation of SNS CobaltII Pincer Model Complexes of Liver Alcohol Dehydrogenase

Published on: March 19, 2020

7.2K

Heteroleptic Copper(I)-Based Complexes Incorporating BINAP and π-Extended Diimines: Synthesis, Catalysis and

Corentin Cruché1, Sayak Gupta2, Jeremy Kodanko2

  • 1Département de Chimie, Centre for Green Chemistry and Catalysis, Université de Montréal, 1375 Avenue Thérèse-Lavoie-Roux, Montréal, QC H2V 0B3, Canada.

Molecules (Basel, Switzerland)
|June 24, 2022
PubMed
Summary

New copper-based photocatalysts show promise for treating triple-negative breast cancer. While initial versions had limited use in certain reactions, modifications improved their effectiveness, with one complex demonstrating significant anticancer activity.

Keywords:
coppermedicinal chemistryphotochemistry

More Related Videos

[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst
09:12

[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst

Published on: May 21, 2019

9.4K
Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
07:20

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents

Published on: May 28, 2014

14.1K

Related Experiment Videos

Last Updated: Sep 6, 2025

Preparation of SNS CobaltII Pincer Model Complexes of Liver Alcohol Dehydrogenase
06:31

Preparation of SNS CobaltII Pincer Model Complexes of Liver Alcohol Dehydrogenase

Published on: March 19, 2020

7.2K
[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst
09:12

[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst

Published on: May 21, 2019

9.4K
Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
07:20

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents

Published on: May 28, 2014

14.1K

Area of Science:

  • Coordination Chemistry
  • Photocatalysis
  • Medicinal Chemistry

Background:

  • Copper complexes with diimine ligands are explored for catalytic and therapeutic applications.
  • Tuning ligand structure is crucial for optimizing photocatalytic and biological activity.
  • Triple-negative breast cancer remains a challenging disease with limited treatment options.

Purpose of the Study:

  • Synthesize and characterize novel copper-based photocatalysts with π-extended diimine ligands.
  • Evaluate their efficacy in single-electron transfer (SET), photoinduced electron transfer (ET), and photoinduced charge transfer (PCET) processes.
  • Assess the potential of these complexes as therapeutic agents against triple-negative breast cancer cell lines.

Main Methods:

  • Synthesis of copper(I) complexes of the type Cu(NN)(BINAP)BF4, where NN represents π-extended diimine ligands.
  • Photocatalytic activity assessment in SET, ET, and PCET reactions.
  • In vitro evaluation of copper complexes against triple-negative breast cancer cell lines, including control experiments with ligands alone.

Main Results:

  • Cu(NN)(BINAP)BF4 complexes exhibited acceptable activity in SET processes but negligible activity in PCET and ET processes.
  • Ligand modification successfully restored suitable activity in ET processes.
  • Copper complexes, not the ligands, were responsible for the observed anticancer activity.
  • A homoleptic complex, Cu(dppz)2BF4, displayed encouraging activity against triple-negative breast cancer cells.

Conclusions:

  • The synthesized copper-diimine complexes show tunable photocatalytic properties, with potential for optimization in ET reactions.
  • Copper complexes, particularly Cu(dppz)2BF4, demonstrate promising cytotoxic effects against triple-negative breast cancer cells.
  • Further investigation into copper complexes as anticancer agents is warranted.