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Advances on Delivery of Cytotoxic Enzymes as Anticancer Agents

Akmal M Asrorov1,2,3, Bahtiyor Muhitdinov1,2, Bin Tu1

  • 1Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.

Molecules (Basel, Switzerland)
|June 24, 2022
PubMed

Insights

Advanced enzyme drug delivery systems show promise for cancer therapy. These smart systems, derived from natural enzymes, are improving tumor targeting and treatment efficacy, with some reaching clinical application.

Area of Science:

  • Biochemistry
  • Oncology
  • Biotechnology

Background:

  • Cancer remains a leading global cause of mortality, driving extensive research into novel therapeutic strategies.
  • Natural enzymes from plant and microbial sources are being explored for their anticancer potential.
  • Smart delivery systems for enzyme drugs have been developed over two decades, with some progressing to clinical trials.

Purpose of the Study:

  • To review advanced delivery systems for enzyme drugs in cancer therapy.
  • To highlight structure-function relationships, mechanisms of action, and targeting strategies.
  • To summarize in vivo and clinical study outcomes of these systems.

Main Methods:

  • Review of existing literature on enzyme drug delivery systems for cancer.
  • Analysis of structure-based functions and mechanisms of action.
  • Evaluation of fused forms with targeting peptides and clinical study results.

Main Results:

  • Advanced delivery systems enhance enzyme drug efficacy through improved targeting and delivery.
  • Various biological, chemical, and physical approaches are employed to optimize these systems.
  • Several enzyme-based delivery systems have reached clinical stages for cancer treatment.

Conclusions:

  • Advanced enzyme drug delivery systems represent a significant development in cancer therapy.
  • These systems offer enhanced targeting and penetration, improving treatment outcomes.
  • Continued research and clinical studies are crucial for realizing the full potential of enzyme-based cancer treatments.
Keywords:
asparaginasecancer therapydiphtheria toxinenzyme drugsexotoxingeloninglucose oxidaseperoxidasetrichosanthin

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