Changes in Water Properties in Human Tissue after Double Filtration Plasmapheresis-A Case Study
Felix Scholkmann1, Roumiana Tsenkova2
1Biomedical Optics Research Laboratory, Department of Neonatology, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland.
Molecules (Basel, Switzerland)
|June 24, 2022
Summary
Double-filtration plasmapheresis (DFPP) alters human tissue water properties, increasing free water and small clusters. This blood purification technique may improve physiological function by enhancing water quality in blood and tissues.
Area of Science:
- Biophysics
- Medical Technology
Background:
- Double-filtration plasmapheresis (DFPP) is a blood purification method.
- Understanding DFPP's physiological impact requires analyzing its effect on tissue composition.
Purpose of the Study:
- To investigate changes in human hand tissue water properties following DFPP treatment using near-infrared (NIR) spectroscopy.
- To correlate observed spectral changes with the effectiveness of DFPP, specifically INUSpheresis with a TKM58 filter.
Main Methods:
- Case study involving NIR spectroscopy measurements on human hand tissue before and after INUSpheresis.
- Analysis of spectral data from both tissue and eluate using the aquaphotomics approach.
- Quantification of water cluster sizes, free water molecules, and hydroxylated water/superoxide levels.
Main Results:
- DFPP treatment led to an increase in small water clusters and free water molecules in human tissue.
- A decrease in hydroxylated water and superoxide in hydration shells was observed post-treatment.
- Eluates showed opposite spectral changes compared to the tissue, indicating substance removal.
Conclusions:
- This study is the first to document alterations in water spectral properties within human tissue after DFPP treatment.
- Observed changes in tissue water quality suggest a potential mechanism for the positive physiological effects of DFPP.
- Improvements in blood and tissue water quality may be linked to the therapeutic benefits of INUSpheresis with the TKM58 filter.
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