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Dipeptide Extract Modulates the Oxi-Antioxidant Response to Intense Physical Exercise
Agnieszka Zembron-Lacny1, Edyta Wawrzyniak-Gramacka1, Anna Książek2
1Department of Applied and Clinical Physiology, Collegium Medicum University of Zielona Gora, 65-046 Zielona Gora, Poland.
Nutrients
|June 24, 2022
Summary
Bioactive dipeptides from chicken extract improve antioxidant status and reduce inflammation following intense exercise. This dietary intervention benefits physically active individuals by modulating oxidative stress and the inflammatory response.
Area of Science:
- Exercise Physiology
- Nutritional Biochemistry
- Sports Science
Background:
- Intense physical exercise elevates reactive oxygen and nitrogen species, leading to oxidative stress.
- Bioavailable dipeptides possess antioxidant properties that can modulate exercise-induced oxidative and inflammatory responses.
Purpose of the Study:
- To investigate the effects of daily chicken breast extract (rich in bioactive dipeptides) intake on the oxi-antioxidant response to intense exercise.
- To evaluate the impact of dipeptide supplementation on oxidative stress markers, antioxidant status, and inflammation in physically active males.
Main Methods:
- A 14-day randomized, placebo-controlled trial involving 20 healthy males.
- Blood samples analyzed pre- and post-exercise for nitric oxide/hydrogen peroxide ratio, total antioxidant status, thiol redox status, 8-isoprostanes, and C-reactive protein.
Main Results:
- Dipeptide intake significantly increased the nitric oxide/hydrogen peroxide ratio post-exercise.
- Total antioxidant and thiol redox status were significantly elevated in the dipeptide group, indicating enhanced antioxidant capacity.
- Dipeptides demonstrated anti-inflammatory effects by reducing C-reactive protein levels post-exercise, with no significant changes in 8-isoprostanes.
Conclusions:
- Pre-exercise intake of bioactive dipeptides enhances the body's antioxidant defenses.
- Dipeptide supplementation effectively modulates the oxi-inflammatory response to strenuous physical activity.
- Bioactive dipeptides show promise for managing oxidative stress and inflammation in athletes and active individuals.
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