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Related Experiment Videos

Intracranial compliance is time-dependent.

C Anile, H D Portnoy, C Branch

    Neurosurgery
    |March 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Intracranial compliance, measured by volume pressure test (VPT), relates to cerebrospinal fluid (CSF) pulse pressure. This study explored time-dependent compliance and pulse pressure relationships in dogs, revealing distinct physical and physiological components.

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    Area of Science:

    • Neurosurgery
    • Neurology
    • Physiology

    Background:

    • Intracranial compliance is a critical characteristic of the intracranial system.
    • Intracranial compliance is typically measured using the volume pressure test (VPT).
    • Intracranial compliance is thought to be related to cerebrospinal fluid (CSF) pulse pressure (delta Pcsf).

    Purpose of the Study:

    • To determine the time-dependent relationship of intracranial compliance.
    • To investigate the relationship between intracranial pulse pressure and compliance.

    Main Methods:

    • Nine dogs were divided into two groups, with skull integrity altered (open or closed) to modify intracranial compliance.
    • Volume pressure tests (VPT) were performed using slow infusion, fast infusion, and bolus injection methods.

    Related Experiment Videos

  • Relationships between diastolic CSF pressure (Pcsf-d), delta Pcsf, infusion rates, and CSF respiratory wave amplitude were analyzed.

    • Main Results:

    • With the skull closed, linear relationships were observed between Pcsf-d and delta Pcsf, infusion methods, and CSF respiratory wave amplitude.
    • With the skull open, linear relationships were maintained only for Pcsf-d vs. delta Pcsf and Pcsf-d vs. bolus injection.
    • Cerebrospinal fluid pulse pressure amplitude remained consistent regardless of skull status at any given Pcsf-d level.

    Conclusions:

    • Intracranial compliance can be differentiated into two components based on the injected volume's time constant.
    • Physical compliance, characterized by a short time constant, is associated with delta Pcsf.
    • Physiological compliance, with a longer time constant, is related to the volume pressure test (VPT).