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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

652
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
652
Cancer Vaccines01:30

Cancer Vaccines

506
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
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B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

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The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
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Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

489
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
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Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

1.1K
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
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B-Cell-Based Immunotherapy: A Promising New Alternative.

Sneh Lata Gupta1, Naeem Khan2, Srijani Basu1,3

  • 1National Institute of Immunology, New Delhi 110067, India.

Vaccines
|June 24, 2022
PubMed
Summary
This summary is machine-generated.

B cells show dual roles in cancer, acting as both anti- and pro-tumorigenic. This review explores B-cell-based immunotherapies, highlighting their potential and challenges for future cancer treatment.

Keywords:
B cell receptorB cellsBregIgGIgM

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Area of Science:

  • Immunology
  • Oncology
  • Biomedical Science

Background:

  • Immunotherapy has evolved significantly, with T-cell-based adoptive immunotherapy showing limited durable benefits for many cancer patients.
  • B cells exhibit complex, dual roles within the tumor microenvironment, influencing anti-tumor and pro-tumorigenic activities.
  • Understanding the factors governing B cell biology and function in tumors is crucial for developing novel therapeutic strategies.

Purpose of the Study:

  • To review the multifaceted roles of B cells in the tumor microenvironment.
  • To discuss the factors influencing B cell biology and function within tumors.
  • To explore current B-cell-based immunotherapies, their clinical applications, and associated challenges.

Main Methods:

  • Literature review of current research on B cells in cancer immunology.
  • Analysis of factors affecting B cell behavior in the tumor microenvironment.
  • Evaluation of B-cell-based immunotherapy strategies and clinical data.

Main Results:

  • B cells possess a dual nature, contributing to both anti-tumor immunity and tumor progression.
  • Various factors within the tumor microenvironment modulate B cell functions.
  • B-cell-based immunotherapies are emerging as a promising area, though clinical challenges remain.

Conclusions:

  • B cells represent a promising, yet complex, target for cancer immunotherapy.
  • Further mechanistic studies are needed to fully harness the anti-tumor potential of B cells.
  • Developing effective B-cell-based therapies requires a deeper understanding of their tumor microenvironment interactions.