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Bovine Astrovirus-A Comprehensive Review
Qinghe Zhu1, Bin Li2, Dongbo Sun1
1Heilongjiang Provincial Key Laboratory of the Prevention and Control of Bovine Diseases, College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, No. 5 Xinfeng Road, Sartu District, Daqing 163319, China.
Viruses
|June 24, 2022
Summary
Bovine astrovirus (BoAstV), a common virus in cattle, has unclear pathogenicity due to co-infections and lack of research models. This review covers BoAstV epidemiology, detection, and potential zoonotic risks.
Area of Science:
- Veterinary Virology
- Molecular Biology
- Epidemiology
Background:
- Bovine astrovirus (BoAstV) is a single-stranded RNA virus first identified in 1978.
- BoAstV exhibits broad tissue tropism, affecting the intestine, nervous system, and respiratory tract in bovines.
- Its prevalence in both healthy and sick cattle, often alongside other pathogens, complicates understanding its role in disease.
Purpose of the Study:
- To review the current knowledge on Bovine astrovirus.
- To consolidate information on BoAstV epidemiology, evolution, detection, and pathogenesis.
- To highlight the potential for cross-species transmission and identify research gaps.
Main Methods:
- Literature review and synthesis of existing research on BoAstV.
- Analysis of epidemiological data and reported prevalence.
- Examination of molecular characteristics and detection methodologies.
Main Results:
- BoAstV is globally distributed and found in various bovine populations.
- Current research lacks definitive data on BoAstV's specific pathogenicity.
- Challenges in BoAstV research include the absence of suitable cell lines and animal models.
- Evidence suggests a potential for BoAstV to transmit across species.
Conclusions:
- Further research is needed to elucidate BoAstV pathogenesis and host-pathogen interactions.
- Development of cell culture systems and animal models is crucial for advancing BoAstV studies.
- Understanding BoAstV's zoonotic potential requires continued investigation.
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