Related Experiment Video

Updated: Sep 6, 2025

Setting-up an In Vitro Model of Rat Blood-brain Barrier BBB: A Focus on BBB Impermeability and Receptor-mediated Transport
16:26

Setting-up an In Vitro Model of Rat Blood-brain Barrier BBB: A Focus on BBB Impermeability and Receptor-mediated Transport

Published on: June 28, 2014

42.6K

Review of Current Strategies for Delivering Alzheimer's Disease Drugs Across the Blood-Brain Barrier

Ka Hong Wong1, Muhammad Kashif Riaz1, Yuning Xie1

  • 1School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China; 16483081@life.hkbu.edu.hk (K.H.W.); kashif@life.hkbu.edu.hk (M.K.R.); 17433606@life.hkbu.edu.hk (Y.X.); bzxiang@hkbu.edu.hk (Z.B.); cxyu2016@hkbu.edu.hk (X.C.); The Key Laboratory of Syndrome Differentiation and Treatment of Gastric Cancer of the State Administration of Traditional Chinese Medicine, Yangzhou 225001, China; zhangxueflora@163.com; Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou 225001, China; School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China; gzlq2002@163.com (Q.L.); chenhuoji2005@126.com (H.C.); Changshu Research Institute, Hong Kong Baptist University, Changshu Economic and Technological Development (CETD) Zone, Changshu 215500, China.

Focus (American Psychiatric Publishing)
|June 24, 2022
PubMed

More Related Videos

Rat Model of Blood-brain Barrier Disruption to Allow Targeted Neurovascular Therapeutics08:43

Rat Model of Blood-brain Barrier Disruption to Allow Targeted Neurovascular Therapeutics

Published on: November 30, 2012

20.4K
Heterotopic Mucosal Engrafting Procedure for Direct Drug Delivery to the Brain in Mice08:25

Heterotopic Mucosal Engrafting Procedure for Direct Drug Delivery to the Brain in Mice

Published on: July 16, 2014

10.9K

Related Concept Videos

Alzheimer's Disease: Treatment01:22

Alzheimer's Disease: Treatment

Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
260
Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
465
The Blood-brain Barrier00:49

The Blood-brain Barrier

Overview
48.5K
Factors Affecting Drug Distribution: Physiological Barriers01:23

Factors Affecting Drug Distribution: Physiological Barriers

Drug distribution in the body is intricately regulated by various physiological barriers that control the passage of substances. These include the capillary endothelial barrier, the blood-brain, blood-cerebrospinal fluid, blood-placental, and blood-testis barriers.
The capillary endothelial barrier allows only smaller molecules below 600 Da (Daltons) to pass through. It also restricts drugs like heparin that are bound to blood components, limiting their movement within the bloodstream.
The...
322
Drug Delivery: Enteral Route01:18

Drug Delivery: Enteral Route

The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
694
Drug Delivery: Parenteral Route01:29

Drug Delivery: Parenteral Route

The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
808