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Reversible Autoimmune Cardiomyopathy Secondary to a Vaccine-Induced Multisystem Inflammatory Syndrome
Ana P Urena Neme1, Elmer R De Camps Martinez1, Constangela Matos Noboa1
1Cardiology, Medicina Cardiovascular Asociada, Distrito Nacional, DOM.
Cureus
|June 24, 2022
Summary
A case report details a young male who developed multisystem inflammatory syndrome after his third SARS-CoV-2 vaccine dose. Prompt treatment with steroids and immunoglobulin led to significant recovery and improved cardiac function.
Area of Science:
- Immunology
- Cardiology
- Public Health
Background:
- The Dominican Republic implemented an early COVID-19 vaccine booster program with a mixed vaccination sequence.
- Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination protocols varied based on vaccine availability.
Observation:
- A 25-year-old male presented with jaundice, vomiting, maculopapular rash, elevated pro-B-type natriuretic peptide (pro-BNP), erythrocyte sedimentation rate (ESR), transaminitis, and thrombocytopenia.
- Echocardiogram revealed signs of heart failure following his third SARS-CoV-2 vaccination dose.
Findings:
- The patient was diagnosed with vaccine-associated multisystem inflammatory syndrome.
- Treatment with corticosteroids and immunoglobulin therapy resulted in marked clinical improvement.
- Follow-up showed resolution of symptoms, normalization of inflammatory markers, and recovery of ejection fraction.
Implications:
- Accurate patient history and chronological event assessment are crucial for diagnosing vaccine-induced multisystem inflammatory syndrome.
- Timely diagnosis and therapeutic intervention significantly improve patient outcomes.
- This case highlights the importance of monitoring for rare adverse events following COVID-19 vaccination.
Keywords:
covid vaccination boostermultisystem inflammatory syndrome (mis)multisystem inflammatory syndrome by vaccination (mis-v)reversible autoimmune cardiomyopathysars-cov-2More Related Videos
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