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Glucose Uptake Measurement and Response to Insulin Stimulation in In Vitro Cultured Human Primary Myotubes
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Glucose Metabolism Intervention-Facilitated Nanomedicine Therapy

Zhiyan Li1, Xianghui Li1, Shichao Ai1

  • 1Department of Gastrointestinal Surgery, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing, 210008, People's Republic of China.

International Journal of Nanomedicine
|June 24, 2022
PubMed

Insights

Starvation therapy uses nanomaterials to target cancer's glucose metabolism, overcoming limitations of traditional methods. This approach shows promise for inhibiting tumor growth and improving cancer treatment efficacy.

Area of Science:

  • Oncology
  • Biomedical Engineering
  • Metabolic Pathways

Background:

  • Cancer cells exhibit increased nutrient uptake and altered metabolic pathways, particularly glucose metabolism.
  • Starvation therapy targets cancer's reliance on glucose, aiming to disrupt tumor growth.
  • Existing starvation therapies face challenges in targeting effectiveness and drug tolerance.

Purpose of the Study:

  • To review recent advancements in nanomaterial-assisted starvation therapy for cancer.
  • To discuss the design and mechanisms of nanosystems used in starvation therapy.
  • To highlight obstacles and future potential for these anticancer strategies.

Main Methods:

  • Review of representative research on nanosystems for starvation therapy.
  • Analysis of traditional glucose oxidase-based treatments.
  • Examination of novel small molecule agents targeting glucose metabolism.

Main Results:

  • Nanomaterial-assisted starvation therapy shows significant progress as monotherapy or combination treatment.
  • Nanosystems offer improved targeting effectiveness and overcome drug tolerance issues.
  • Diverse strategies, including glucose oxidase and small molecule agents, are being developed.

Conclusions:

  • Nanomaterial-assisted starvation therapy represents a promising strategy for cancer treatment.
  • Further research is needed to address obstacles and advance clinical translation.
  • The integration of nanotechnology offers new avenues for targeting cancer metabolism.
Keywords:
cancer metabolismcombined therapynanomedicinestarvation therapy

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