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Reducing antithrombotic-related bleeding risk in urgent and emergency cardiac surgery

Amer Harky1, Abdul Badran2

  • 1Cardiothoracic Surgery SpR Department of Cardiothoracic Surgery, Liverpool Heart and Chest Hospital, Thomas Drive, Liverpool, L14 3PE.

The British Journal of Cardiology
|June 24, 2022
PubMed

Insights

CytoSorb is a blood purification technology used in cardiac surgery. It effectively removes antiplatelet and anticoagulant drugs, helping to prevent bleeding complications.

Area of Science:

  • Cardiovascular Surgery
  • Blood Purification Technologies
  • Pharmacology

Background:

  • On-pump cardiac surgery carries risks of bleeding complications.
  • Management of antiplatelet and anticoagulant medications is crucial during surgery.
  • Extracorporeal blood purification offers potential solutions for drug removal.

Purpose of the Study:

  • To review the role of CytoSorb technology in managing bleeding risks during cardiac surgery.
  • To evaluate the efficacy of CytoSorb in removing specific drugs like ticagrelor and rivaroxaban.
  • To summarize recent clinical evidence supporting CytoSorb's application.

Main Methods:

  • Literature review of clinical studies and relevant publications.
  • Focus on CytoSorb technology and its application in extracorporeal circulation.
  • Analysis of data concerning drug removal and bleeding complications.

Main Results:

  • CytoSorb demonstrates potential in removing ticagrelor and rivaroxaban from blood.
  • The technology is indicated for preventing bleeding complications in cardiac surgery.
  • Clinical studies provide preliminary evidence of its effectiveness.

Conclusions:

  • CytoSorb is a relevant technology for blood purification in cardiac surgery settings.
  • Effective removal of anticoagulants and antiplatelet agents can mitigate surgical bleeding.
  • Further clinical research is warranted to solidify its role and optimize its use.

Keywords:
CytoSorb®bleedinghaemoadsorptionresternotomyrivaroxabansurgeryticagrelortransfusion

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