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Updated: Sep 6, 2025
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Alpha-1-Antitrypsin Experience for Steroid-Resistant Acute Graft-Versus-Host Disease
Derya Koyun1, Güldane Cengiz Seval1, Ekin Kırcalı1
1Ankara University School of Medicine, Hematology Department, Ankara, Turkey.
Abstract:
Steroid-refractory acute graft-versus-host disease (SR-aGVHD) treatment has a low response rate and a high risk of infection in allogeneic hematopoietic stem cell transplantation. The standard approach to be applied in this situation is uncertain. This study aims to evaluate the effectiveness and safety of alpha-1-antitrypsin (AAT). In the study, the results of five SR-aGVHD patients received AAT evaluated. Complete response was seen 2 of four patients with gastrointestinal (GI) aGVHD, partial response in one GI and one liver aGVHD. The overall response rate was 80%. AAT is an effective and safe treatment option in SR-aGVHD.
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