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Updated: Sep 6, 2025
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Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis
Published on: June 3, 2016
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ENDOCRINE DISRUPTING CHEMICALS AND OBESITY: THE EVOLVING STORY OF OBESOGENS.
D Micić1, S Polovina2, D Micić3
1Serbian Academy of Sciences and Arts - Department of Medical Sciences, Belgrade, Serbia.
Acta Endocrinologica (Bucharest, Romania : 2005)
|June 24, 2022
Summary
Environmental obesogens, chemicals that promote obesity, are increasingly linked to the global obesity pandemic. Understanding these endocrine disruptors is crucial for developing effective prevention strategies.
Area of Science:
- Environmental Science
- Endocrinology
- Toxicology
Background:
- The global rise in obesity necessitates exploring beyond the traditional caloric model.
- Endocrine disruptors (EDs), specifically obesogens, are implicated in the pathogenesis of obesity.
- The obesogen hypothesis links increased exposure to exogenous pollutants post-WWII with the current obesity epidemic.
Discussion:
- Obesogens disrupt adipocyte development and lipid accumulation, altering metabolic balance and appetite regulation.
- Obesogens contribute to increased body fat mass through various mechanisms, including impaired adipocyte programming and altered neuroendocrine control.
- The spectrum of obesogens includes industrial chemicals, biocides, pharmaceuticals, pollutants, and smoke.
Key Insights:
- Obesogens interfere with the development and function of adipose tissue.
- These environmental chemicals can dysregulate the hormonal control of appetite and satiety.
- Scientific evidence increasingly supports the role of obesogens in contributing to obesity.
Outlook:
- Further research into obesogens and their mechanisms can inform obesity prevention.
- Translational studies are essential to elucidate the proposed mechanisms of obesogen action.
- Mitigating environmental exposure to obesogens may reduce the deleterious effects on human health and development.
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