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Updated: Sep 6, 2025
03:55
Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer
Published on: June 9, 2023
620
SURVIVIN POSITIVITY AND PROGNOSTIC FACTORS IN PAPILLARY THYROID CARCINOMAS
E Usturali Keskin1,2,3,4,5, E Taştekin1,2,3,4,5, N Can1,2,3,4,5
1Dept. of Pathology, Trakya University, Faculty of Medicine, Ankara, Turkey.
Acta Endocrinologica (Bucharest, Romania : 2005)
|June 24, 2022
Summary
Survivin expression in papillary thyroid carcinoma correlates with tumor size, lymphovascular invasion, and intraglandular extension. This finding suggests survivin may indicate a more aggressive tumor, potentially influencing treatment strategies.
Area of Science:
- Oncology
- Molecular Biology
- Pathology
Background:
- Papillary thyroid carcinoma (PTC) are indolent tumors.
- Survivin is a protein that regulates cell cycle and inhibits apoptosis.
- Increased survivin expression is linked to aggressive thyroid tumors.
Purpose of the Study:
- Investigate the relationship between survivin expression and prognostic factors in PTC.
- Determine if survivin is a reliable prognostic marker in papillary thyroid carcinomas.
Main Methods:
- Compared clinicopathological findings with immunohistochemical survivin positivity in 109 patients undergoing thyroidectomy.
- Analyzed correlations between survivin expression and various tumor characteristics.
Main Results:
- Tumor size, lymphovascular invasion, absence of stromal response, and intraglandular extension were significantly correlated with survivin expression.
- No significant correlation was found with other clinicopathological parameters.
Conclusions:
- Survivin expression is associated with aggressive features in papillary thyroid carcinoma.
- Survivin may serve as a prognostic marker, potentially guiding preoperative and postoperative treatment decisions.
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