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Intracranial Injection of Adeno-associated Viral Vectors
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Probable Cerebral Amyloid Angiopathy-Related Inflammation Associated With Sitravatinib: A Case Report

Christopher Ray1, Kalen Dionne1

  • 1Department of Neurology, Washington University School of Medicine.

Neurology. Clinical Practice
|June 24, 2022
PubMed
Abstract

Insights

A patient developed neurological symptoms including encephalopathy and seizures after starting sitravatinib. This case highlights potential cerebral amyloid angiopathy-related inflammation (CAA-ri) linked to tyrosine kinase inhibitors.

Area of Science:

  • Neuroscience
  • Oncology
  • Immunology

Background:

  • Sitravatinib is a novel tyrosine kinase inhibitor used in cancer therapy.
  • Neurological side effects associated with tyrosine kinase inhibitors are increasingly recognized.

Observation:

  • A 67-year-old male patient developed encephalopathy, headaches, and seizures post-sitravatinib initiation.
  • Brain MRI showed microhemorrhages and vasogenic edema, indicative of cerebral amyloid angiopathy-related inflammation (CAA-ri).

Findings:

  • The patient's symptoms improved with high-dose methylprednisolone treatment.
  • This case suggests a potential link between sitravatinib and CAA-ri.

Implications:

  • This case highlights the importance of recognizing and managing drug-induced neurologic autoimmunity.
  • Further research is needed to understand the pathophysiology of CAA-ri in patients treated with immunomodulatory agents like sitravatinib.

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