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The Significance of the Ocular Adverse Effect Induced by Systemic Taxane Application
Ya-Ting Ye1,2,3, Zi-Yi Zhou1, Li-Shi Wen1
1Department of Ophthalmology, Eye Institute of Chinese PLA, Xijing Hospital, Fourth Military Medical University, 710032 Xi'an, Shaanxi, China.
Abstract:
In recent years, in-depth research on anti-tumor therapy has brought the emergence of new active chemotherapeutic agents and combination regimens. However, as one of them, taxane drugs are widely used in clinical practice, but it should be noted that many side reactions caused by their application bring some difficulties to routine management. Among the side reactions related to taxane anti-tumor therapy, ocular adverse reactions are occasionally reported and are not life-threatening but may seriously affect patients' life quality. Thus, the continuation, reduction and cessation of taxane chemotherapy still need to be further evaluated by ophthalmologists and oncologists once the side effects show up. To prevent ocular side reactions, close attention should be paid to complications during medication. To facilitate the oncology department and ophthalmologists to comprehensively understand the ophthalmic adverse reactions of taxane drugs and their possible mechanisms and improve drug use efficiency, we collected relevant literature and reviewed and provided some suggestions for the monitoring and managing of ophthalmic toxicity.
Insights
Taxane chemotherapy can cause ocular side effects, impacting patient quality of life. This review offers guidance for oncologists and ophthalmologists on managing these taxane-induced ophthalmic toxicities.
Area of Science:
- Oncology
- Ophthalmology
- Pharmacology
Background:
- Taxane chemotherapy is a cornerstone in anti-tumor therapy.
- While effective, taxanes can cause various side reactions, including ocular adverse events.
- Ophthalmic toxicities, though not life-threatening, significantly affect patient quality of life.
Purpose of the Study:
- To comprehensively review ophthalmic adverse reactions associated with taxane drugs.
- To elucidate the possible mechanisms underlying taxane-induced ocular toxicity.
- To provide suggestions for monitoring and managing these side effects in clinical practice.
Main Methods:
- Literature review of relevant studies on taxane chemotherapy and ocular adverse reactions.
- Analysis of reported ophthalmic complications and their potential mechanisms.
- Synthesis of clinical management strategies for ophthalmologists and oncologists.
Main Results:
- Ocular adverse reactions are occasionally reported with taxane use.
- These reactions can seriously impact patients' quality of life, necessitating careful management.
- Effective monitoring and management strategies are crucial for optimizing taxane chemotherapy.
Conclusions:
- Ophthalmologists and oncologists must collaborate to evaluate and manage taxane-induced ocular toxicity.
- Close attention to potential complications during taxane administration is essential.
- Improved understanding and management can enhance the efficiency and safety of taxane chemotherapy.
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